SYNTHESIS AND INVESTIGATION OF INHIBITOR PROPERTIES OF NEW ANALOGUE OF RIBAVIRIN AGAINST SOYBEAN LIPOXYGENASE
RAYA N. RAYKOVA*, LACHESAR S. MANOVSKI, DESSISLAVA A. MARINKOVA, LYUBOV K. YOTOVA, DANCHO L. DANALEV
Department of Biotechnology, University of Chemical Technology and Metallurgy, 1756, Sofia, Bulgaria
*Corresponding author: raianikolova@gmail.com
Keywords: inhibitors, ribavirin analogue, soybean lipoxygenase, Lewis acids, thiourea
Abstract: The aim of this work was to synthesize an analogue of ribavirin with potential inhibitor properties against soybean lipoxygenase (LOX). The newly synthesized inhibitor mimics the well-known natural inhibitor of different enzymatic systems ribavirin, but differ by the substitution of triazine base with the residue of thiourea, containing primary NH2 group.
Different conditions of reactions of synthesis were studied, using a donor-acceptor mechanism in the presence of several Lewis acids.