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DTasheva webpage 2017

Assoc. Prof. Dr. Donka Tasheva

Sofia University “St. Kl. Ohridski”, Faculty of Chemistry and Pharmacy

Department of Organic Chemistry and Pharmacognosy, room 606

1 J. Bourchier blvd, 1164, Sofia, Bulgaria

Phone: +359 2 8161 437

e-mail: dtasheva@chem.uni-sofia.bg

Education and academic degrees

1998 – PhD in Organic chemistry

1986 – M.Sc. in Chemistry, Sofia University “St. Kl. Ohridski”

Professional experience

2011 – Associate Professor in Organic chemistry (organic synthesis), Department of Organic chemistry and pharmacognosy, Sofia University “St. Kl. Ohridski”

1994 – 2011 Assistant Professor, Department of Organic chemistry, Sofia University “St. Kl. Ohridski”

Additional academic positions, awards and guest professorships:

2016 – Director of Master Programme “Modern Methods of Synthesis and Analysis of Organic Compounds”

Research interests

Organic synthesis – Synthesis of analogues of non-proteinogenic α-amino acids with potential pharmacological application, Phase transfer Catalysis

Synthesis and application of new fluorogenic histochemical substrates and specific inhibitors of proteinases, markers for malignant diseases

Selected publications (up to 5)

Ivaylo P. Ivanov, Mashenka B. Dimitrova, Donka N. Tasheva, Diana V. Cheshmedzhieva, Valentin S. Lozanov, Sonia V. Ilieva, Synthesis, structural analysis and application of a series of solid-state fluorochromes – aryl hydrazones of 4-hydrazino-N-hexyl-1,8-naphthalimide, Tetrahedron, 2013, 69(2), 712-721.

M. Dimitrova, D. Tasheva, I. Ivanov, Development of a fluorescent method for the in situ imaging of gamma-glutamyl transpeptidase activity. Comparison with the methods in use, Copmt. Rend. Acad. Bulg. Sci. 2011, 64 (12), 1701-1706.

Cheshmedzhieva, D., Ivanova, P., Stoyanov, S., Tasheva, D., Dimitrova, M., Ivanov, I., Ilieva, S. Experimental and theoretical study on the absorption and fluorescence properties of substituted aryl hydrazones of 1,8-naphthalimide, Physical Chemistry Chemical Physics, 2011, 13 (41), 18530-18538.

S. Ilieva, D. Cheshmedzhieva, D. Tasheva, The origin of diastereoselectivity in the Michael addition reaction: A computational study of the interaction between CH-acidic Schiff base and α,β-unsaturated ketones, Tetrahedron, 2010, 66, 5168-5172.

I. Ivanov, D. Tasheva, R. Todorova, M. Dimitrova, Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I, Eur. J. Med. Chem. 2009, 44, 384-3923.

Scopus Author ID

Projects (last 5 years)

1. „Materials Networking contract, programme ”Horizon 2020”, 2016, team member

2. Development of Electronic Forms of Distance Training in Faculty of Chemistry and Pharmacy, Sofia University “St. Kl. Ohridski"- The PROGRAM HUMAN RESOURCES, CONTRACT № BG051PO001- 4. 3. 04 - 0033; 2012 – 2014, team member

3. Molecular design of specific substrates and inhibitors of fibroblast activation protein α - marker enzyme for malignancies, contract Т02/25, 2014, team member

4. Synthesis of Pyrroline and Pyrrolidine Carboxylic Acid Derivatives with Biological Activity, contract № 80-10-6/2017 (Scientific Fund Sofia University “St. Kl. Ohridski”), project leader

5. Synthesis, biochemical and cytochemical investigations of a specific inhibitors for Aminopeptidase A contract № 29/2015 (Scientific Fund Sofia University “St. Kl. Ohridski”, project leader

6. Synthesis and Application of Ffluorogenic Substrate for Cyto- and Histochemical Localisation of Aminopeptidase A, contract № 119/2013 (Scientific Fund Sofia University “St. Kl. Ohridski”), project leader

7. Synthesis, chromatographic and MS Properties on certain α-Amino Acids, contract № 48/2012 (Scientific Fund Sofia University “St. Kl. Ohridski”), project leader

8. Molecular design, Synthesis and Application of fluorpogenic substrates for the histochemical localization of TPP I contract № “116/2011 (Scientific Fund Sofia University “St. Kl. Ohridski”), project leader

Other professional activities

Referee of projects in European Research Council (ERC) - 2016

Referee of publications in: Bulg. Chem. Commun.

Head Mentor of the Bulgarian Team for the partipation in International Chemistry Olympiad – 2004- to present

Textbooks and manuals:

М. Yankov, A. Sidjimov, H. Chanev, Al. Dobrev, R. Nikolova, Ts. Cholakova, D. TashevaTasks in Organic Chemistry”, Sofia, 2011

Teaching

Lectures:

Organic chemistry II – Bachelor programme Computer Chemistry and Eco Chemistry, 60 h

Organic chemistry II – at Bachelor programme Chemical Engineering and Contemporary Material and Nuclear Chemistry, 45 h

Bioorganic Chemistry – at Bachelor programme Eco Chemistry, 30 h

Organic chemistry II – at Bachelor programme Optometry, Faculty of Physics, 45 h

Reaction Mechanisms in Organic Chemistry – at all bachelor programmes in FCP, 30 h (elective)

Structure and Reactivity of Organic Compounds - at Master Degree Programme “Modern Methods of Synthesis and Analysis of Organic Compounds”

Biotransformations of Organic Compounds - at Master Degree Programme “Modern Methods of Synthesis and Analysis of Organic Compounds”

Practicums:

Seminars and practical exercises in Organic Chemistry – all bachelor programmes in FCP

Seminars in Bioorganic Chemistry and Reaction Mechanisms in Organic Chemistry