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CV

 

Galina Gencheva

Email: ggencheva@chem.uni-sofia.bg

Тел.: + 359 2 8161 208/347/394

Факс: + 359 2 9625438

Sofia University „St. Kliment Ohridski”

Faculty of Chemistry and Pharmacy

1164 Sofia, 1 James Bourchier Blivd.

 

Education

  • M. Sc. – Chemistry, Inorganic and Analytical Chemistry, University of Sofia, “St. Kliment Ohridski”, 1986
  • Ph.D - Analytical Chemistry, University of Sofia, “St. Kliment Ohridski”, 1993

Professional Experience

  • Associate Professor, Analytical Chemistry, University of Sofia „St. Kliment Ohridski”, 2004 - .
  • Head Assistant Professor, Analytical Chemistry, University of Sofia „St. Kliment Ohridski”, 1997 – 2004;
  • Chief Assistant Professor, Analytical Chemistry, University of Sofia „St. Kliment Ohridski”, 1996 – 1997;
  • Senior Assistant Professor in Analytical Chemistry, University of Sofia „St. Kliment Ohridski”, 1996;
  • Assistant Professor, Analytical Chemistry, Inorganic Chemistry, University of Sofia „St. Kliment Ohridski”, 1993 – 1996;
  • Assistant Professor in Analytical Chemistry, University of Sofia „St. Kliment Ohridski”, 1992 – 1993;

Specializations and Visiting Researcher at:

  • Prof. Dr. Dr.h.c. Bernt Krebs, Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany
  • Prof. Dr. Kaspar Hegetschweiler, Univerisitaet des Saarlandes, Saarbruecken, Germany
  • Department of Chemistry and Biochemistry, North Dakota State University, United States – Angel Ugrinov, PhD

Research Interests

  • Instrumental methods and their application for molecular structure determination and quantitative analysis: Infrared and Raman Spectroscopy, Ultraviolet and Visible Absorption Spectroscopy, Electro Paramagnetic Resonance, Nuclear Magnetic Resonance, Magnetic Measurements, Single Crystal X-Ray Diffraction, Electroanalytical Methods.
  • Synthesis, structure, physicochemical properties and application of coordination compounds designed as new materials and antiproliferative drugs.

Selected Publications

1. G. Momekov, I. Ugrinova, E. Pasheva, D. Tsekova, G.Gencheva: Cellular Pharmacology of Palladinum(III) Hematoporphyrin IX Complexes: Solution Stability, Antineoplastic and Apoptogenic Activity, DNABinding, and Processing of DNA-Adducts, Int. J. Mol. Sci. 19, (2018) 2451-2453; doi:10.3390/ijms19082451.

2. Zh. V. Georgieva, A. G. Ugrinov2, R. P. Nikolova3, B. L. Shivachev3, S. Y. Zareva1, S. G. Varbanov4, T. D. Tosheva4, G. G. Gencheva: Coordination of bis((dimethylphosphinyl)- methyl)amine to copper(II). Synthesis and single-crystal structure of its mononuclear octahedral copper(II) complex, Bulg. Chem. Commun. 50J (2018) 251-259.

3. S.Y. Zareva, G. G. Gencheva, Crystal structure and spectral study of 3-methylpyridazinium hydrogensquarate, Bulg. Chem. Commun. 50J (2018) 123–129.

4. N. Doneva, N . Boseva, G. Gencheva, D. Tsekova, G. Momekov: Oncopharmacological evaluation of cytotoxic platinum, palladium and gold metal complexes with porphyrin ligands, 115 (2014) 313-313.

5. D. Tsekova, P. Gorolomova, G. Gochev, V. Skuryev, G. Momekov, D. Momekova, G. Gencheva: Synthesis, structure and in vitro cytotoxic studies on novel paramagnetic palladium(III) complexes with hematoporphyrin IX, Journal of Inorganic Biochemistry, 124 (2013) 54-62. doi: 10.1016/j.jinorgbio.2013.03.012

6. P. Gorolomova, R. Petrova, B. Shivachev, V. Ilieva, D. Tsekova, T. Tosheva, E. Tashev, S. Varbanov, G. Gencheva: Theoretical and experimental studies on the coordination ability of 1,4-bis(dimethylphosphinylmethyleneoxy) benzene, Bulgarian Chemical Communications 43 (2011) 244-253.

7. G. Gencheva, D. Tsekova, G. Gochev, G. Momekov, G. Tyuliev, V. Skumryev, M. Karaivanova, P. R. Bontchev: Synthesis, structural characterization and cytotoxic activity of novel paramagnetic platinum hematoporphyrin IX complexes – potent antitumour agents, Metal-Based Drugs, Vol. 2007 (2007), Article ID 67 376, 13 pages. doi:10.1155/2007/67376.

8. G. Momekov, D. Ferdinandov, S. Konstantinov, S. Arpadjan, D. Tsekova, G. Gencheva, P. R. Bontchev, M. Karaivanova: In vitro evaluation of a stable monomeric gold(II) complex with hematoporphyrin IX: Cytotoxicity against tumor kidney cells, cellular accumulation and induction of apoptosis, Bioinorganic Chemistry and Applications, Volume 2008 (2008), Article ID 367471, 8 pages. doi: 10.1155/2008/367471.

9. G. Momekov, M. Karaivanova, I. Ugrinova, E. Pasheva, G. Gencheva, D. Tsekova, S. Arpadjan, P. R. Bontchev: In vitro pharmacological study of monomeric platinum(III)hematoporphyrin IX complexes, Invest. New Drugs, (2010), 10 pages. doi:10.1007/s10637-010-9412-8.

10. M. Lalia-Kantouri, N. I. Dodoff, G. Gencheva, I. Karadjova, “Cyclic Method for Preparation of Potasium Tetrachloroplatinate (K2PtCl4)”: Hellenic Patent No 1007317 (2011); Reg. No 20100100327 (2010); Int. Cl: C01G 55/00 (2011)(in Hellenic). http://www.obi.gr/obi/Portals/0/ImagesAndFiles/Files/EDBI/2011/A/EDBI_A_2011_06.pdf

List of Publications

Project Activity – (Research Projects in the last 5 years)

  • “Rational Design of New Metal-Based Antitumor Agents, National Science Fund, Ministry of Education and Science, 2016 –.
  • “Studies on the advantages of nonclassical antitumor agents based on platinum complexes - New PtIV complexes with N, O- containing ligands, Scientific Research Fund, University of Sofia, “S. Kliment Ohridski”, 2016.
  • “ Ruthenium versus platinum: Rational design and synthesis of potential antitumour agents. An experimental and theoretical study of the structure-activity relationships ”, National Science Fund, Ministry of Education and Science, 2010 – 2013.
  • “Effects of the ligand structure at construction and properties of new coordination compounds designed as non-classical antitumor agents”, Scientific Research Fund, University of Sofia, “S. Kliment Ohridski”, 2014.
  • “Structural Analysis of the coordination compounds of metals from the first transitions series with thw ligands: 1,3,5-tris(dimethylphosphinylmethoxy)benzene and bis((dimethylphosphinyl)methyl)amine”, Scientific Research Fund, University of Sofia, “S. Kliment Ohridski”. 2012.

Teaching Activity

Period from - to Discipline Specialty
2009 - Instrumental Methods II Bachelor’s program: Chemistry, Chemistry and Ecology, Nuclear Chemistry, Engineering and Modern materials Chemistry and Informatics
2009 - Vibrational Spectroscopy – Methods and Application Methods and Application Elective course for Bachelors, All specialities
2009 - Modern Methods in Molecular Spectroscopy Master Program “Modern Spectral and Chromatographic Methods of Analysis”
2010 - Infrared and Raman Spectroscopy MS
2010 - Electron spectroscopy (UV/VIS, fluorescence) MS
2006 - Electroanalytical Methods Masters and Bachelor programs
2003 - Coordination Compounds in Analytical Chemistry chemistry
2005 – 2009 Analytical Chemistry I & II Bachelor’s programs: chemistry and ecology, computational chemistry, biology, microbiology

External Scientific Service Activities

- Member of Editorial Board of Bulgarian Chemical Communication – Special Issue of 2015, dedicated to Vth National Crstallographic Symposium, 2014, Sofia.

- Member of “Bulgarian Crystallographic Association” since 2010 - presentReviewer of Manuscripts for:

Reviewer of Manuscripts for: European Journal of Medicinal Chemistry; Asian Chemistry Letters, Bulgarian Chemical Communications, Chemistry, Anti-Cancer Agents in Medicinal Chemistry, etc.

Textbooks and Teaching Aids

- G. Pekov, D. Tsekova, G. Gencheva: Tasks in analytical chemistry. Processes and their application in chemical analysis, University Press, Sofia University “St. Kliment Ohridski”, 2016.