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Poli

Paulina Gorolomova

Email: ahpg@chem.uni-sofia.bg

Phone: + 359 888913196

Fax: + 359 2 9625438

Sofia University „St. Kliment Ohridski”

Faculty of Chemistry and Pharmacy

1164 Sofia, 1 James Bourchier Blivd.

 

Education

  • M. Sc. – “Modern spectral and chromatographic methods of analysis”, University of Sofia, 2008
  • Ph.D – “Analytical Chemistry”, University of Sofia, 2013

Professional Experience

  • Specialist-chemist of Analytical Chemistry, University of Sofia, 2012 -.

Specializations and Visiting Researcher at:

  • TUD, International The CAMD Summer School Electronic Structure Theory and Materials Design 14 - 20 August 2010, Copenhagen, Denmark.

Research Interests

  • Theoretical methods
  • Quantum-Chemical calculations
  • Coordination Chemistry
  • Molecular Spectroscopy

Selected Publications

  1. P. J. Gorolomova, R. P. Nikolova, B. L. Shivachev, V. I. Ilieva, D. Ts. Tsekova, T. D. Tosheva, E. S. Tashev, S. G. Varbanov, G. G. Gencheva,* “Theoretical and experimental studies on the coordination ability of 1,4 - bis (dimethylphosphinylmethyleneoxy) benzene”, Bulgarian Chemical Communications, Volume 43, Number 2 (pp. 244–253) 2011.
  2. Daniela Tsekova, Paulina Gorolomova, Georgi Gochev, Vassyl Skumryev, Georgi Momekov, Denitsa Momekova, Galina Gencheva, “Synthesis, structure and in vitro cytotoxic studies of novel paramagnetic palladium(III) complexes with hematoporphyrin IX”, Journal of Inorganic Biochemistry, DOI: doi: 10.1016/j.jinorgbio.2013.03.012, Accepted 22 March 2013

Project Activity – (Research Projects in the last 5 years)

  • “Rational Design of New Metal-Based Antitumor Agents”, National Science Fund, Ministry of Education and Science, N09/61, 2017-2020
  • “Ruthenium versus platinum: Rational design and synthesis of potential antitumour agents. An experimental and theoretical study of the structure-activity relationships ”, National Science Fund, Ministry of Education and Science, DDWU/02/66 2010–2014 (ІІ Stage).
  • Financing of scientific forum - IInd National Crystalographic Symposium, Sofia University Science Fund, 107/2010, ended.
  • “New coordination compounds of platinum and gold with dipyridylamine and dipyridylketone - experimental and theoretical studies of solid state structure and solution chemistry”, Sofia University Science Fund, 068/2010, ended.
  • “Structural characterization of new crystal materials”, National Science Fund, Ministry of Education and Science, DRNF 02/1/14.12.2009, ended.
  • “Complexes of metals from the first transition series with phosphineoxide and N-containing phosphineoxide ligands – new synergists at the neutral metal complexes extraction”, Sofia University Science Fund, 112/2009, ended.

Teaching Activity

Period from - to Discipline Specialty

02 – 06 2010

02 – 06 2011

04 2011

02 – 06 2012

10 2014 – 01 2015

Analytical Chemistry 2

(Laboratory Exercace)

Analytical Chemistry 2

(Laboratory Exercace)

NMR spectroscopy – Instrumental Methods of the Chemistry 2

(exercace)

Analytical Chemistry 2

(Laboratory Exercace)

Modern Molecular Spectroscopy Methods

(Exercace)

Computer Chemistry

Molecular Biology

Nuclear Chemistry, Ecochemistry, Chemistry

Ecology

Modern spectral and chromatographic methods of analysis

External Scientific Service Activities

  • Member of Bulgarian Crystallographic Association.
  • Member of European Uniom of Chrystallography.
  • Member of Societe de Chimie Therapeutique.

Conferences

  • NMR spectroscopy for life sciences, Bulgarian Academy of Science, Institute of Organic Chemistry with Center of Phytochemistry, Sofia, 8 – 10 April 2009
  • International School on Fundamental Chrystallography: Introduction on the international tables for Chrystallography, September 30 – October 5 2013, Sofia-Gyulechitsa, Bulgar
  • D. Tsekova, R. Petrova, B. Shivachev, P. Gorolomova, V. Ilieva, S. Varbanov, G. Gencheva, „Transition metal complexes with dimethyl (methyleneoxyaryl) phosphine oxides –based ligands. Crystal and molecular structure of 1,4-bis(dimethylphosphinylmethyleneoxy)benzene and Copper(II) complex of 1,3-bis(dimethylphosphinylmethyleneoxy)benzene”, Ist National Crystallographic Symposium, October 22 – 23 2009, Sofia, Bulgaria, p. 129.
  • P. Gorolomova, G. Gencheva, „Theoretical study on the coordination ability of 2,2’-dipyridylketone (dpk). Stabile Pt(IV) complex of its hydrated gem-diol form”, Fourth Humboldt Conference on Computational Chemistry, July 12 – 15 2010, Varna, Bulgaria, p. 34.
  • G. Gencheva, D. Tsekova, P. Gorolomova, V. Ilieva, R. Petrova, B. Shivachev, T. Tosheva, E. Tashev, S. Varbanov, “Copper(II) Coordination Polymers with Dimethyl-(methyleneoxyaryl) Oxydes – based ligands: Synthesis, Structure and Properties”, SIZEMAT 2, September 19 – 21 2010, Nessebar, Bulgaria, p. 51.
  • а)P.Gorolomova, R. Petrova, B. Shivachev, V. Ilieva, T. Tosheva, E. Tashev, S. Varbanov G.Gencheva, “Theoretical and experimental studies on the coordination ability of 1,4-bis(dimethylphosphinylmethyleneoxy)benzene”, IInd National Crystallographic Symposium, October 21 – 23 2010, Sofia, Bulgaria, p. 48; b) V.Ilieva, R. Petrova, B. Shivachev, P. Gorolomova, T. Tosheva, E. Tashev, S. Varbanov G.Gencheva, “Structural diversity in Zinc(II) coordination polymers constructed with dimethyl(methyleneoxyaryl) phosphine oxide-ligands” ”, IInd National Crystallographic Symposium, October 21 – 23 2010, Sofia, Bulgaria, p. 42.
  • а) P.Gorolomova, G. Gencheva, “Theoretical study on coordination ability of the ligands 2,2’-dipyridylamine and 2,2’-dipyridylketone”, CPMD2011: Extending the limits of Ab initio Molecular Dynamics Simulations for Chemistry, Materials Science and Biophysics, September 5-9 2011, Barcelona, Spine, p. 115; b) I. Koleva, P. Gorolomova, G. Gencheva, “Density Functional Theory study on the Molecular Structure and Reactivity of 5-Fluoruracil”, CPMD2011: Extending the limits of Ab initio Molecular Dynamics Simulations for Chemistry, Materials Science and Biophysics, September 5-9 2011, Barcelona, Spine, p. 112.
  • P.Gorolomova, R. Nikolova, B. Shivachev, V. Skumryev, D. Tsekova, V. Ilieva, S. Varbanov, T. Tosheva, E. Tashev, G. Gencheva, “Series of Manganese(II) coordination polymers containing dimethyl(methyleneoxyaryl) phosphine oxide-bridges and inorganic ligands: Synthesis, single-crystal structure and magnetic properties”, IIIrd National Crystallographic Symposium, October 3 – 5 2011, Sofia, Bulgaria, p. 25.
  • P. Gorolomova, I. Koleva, V. Anastasova, M. Vrazhilova, G. Gencheva, „Theoretical studies on the coordination ability of series N-, O-, and N,O-containing ligands”, Научна конференция посветена на международната година на химията, Ноември 21 2011, София, България.
  • P. Gorolomova, Zh. Georgieva, B. Shivachev, R. Petrova, S. Varbanov, T. Tosheva, E. Tashev, D. Tsekova, S. Zareva, S. Tayandzhieva, Yo. Zhelyazkova, V. Skumryev, G. Gencheva, „Synthesis, Structural Characterization and Properties of Transition metals coordination polymers constructed by tertiary phosphine oxide-ligands”, Ежегодна научна конференция на Института по Органична химия с център по фитохимия към БАН, Април 25-26 2012, София, България.
  • a)P. Gorolomova, S. Chakarova, S. Simova, G. Gencheva, 14th Central and Eastern European NMR Symposium & Bruker Users ‘ Meeting, Септември 16-19 2012 Златни пясъци, България, p60; b) P. Gorolomova, P. Shestakova, S. Todorova, V. Velcheva, G. Gencheva, 14th Central and Eastern European NMR Symposium & Bruker Users ‘ Meeting, Септември 16-19 Златни пясъци, България, p78.
  • Paulina Gorolomova, Zhana Georgieva, Rositsa Petrova, Boris Shivachev, Daniela Tsekova, Sonya Zareva, Tania Tosheva, Sabi Varbanov, Vassil Skumryev and Galina Gencheva, 11th European Workshop on Phosphorus Chemistry, “SERIES OF TRANSITION METAL COORDINATION POLYMERS WITH N,O-CONTAINING ORGANIC LINKERS BASED ON TERTIARY PHOSPHINE OXIDES – SYNTHESIS, STRUCTURE AND PROPERTIES”, March 24-26, 2014, Sofia, Bulgaria, p. 67.
  • а) P. Gorolomova, B. Krebs, R. Petrova, B. Shivachev, S. Simova, G. Momekov, G. Gencheva, STRUCTURE, SPECTROSCOPIC PROPERTIES AND IN VITRO ANTIPROLIFERATIVE EFFECTS OF NEW AuIII COMPLEXES WITH DIPYRIDIN-2-YLAMINE, p. 51; б) S. Chakarova, P. Gorolomova, B. Krebs, G. Momekov, G. Gencheva, ”STABILIZATION OF HIGHER OXIDATION STATES OF PLATINUM BY COORDINATION WITH FLEXIBLE N,O,N-LIGAND DIPYRIDIN-2-YLMETHANONE AND RIGID N,N-LIGAND PYRIDINE-2-AMINE – SYNTHESIS, CRYSTAL STRUCTURE AND CYTOTOXICITY” , p.32, в) D. Tsekova, Y. Zhelyazkova, R. Petrova, B. Shivachev, N. Vassilev, P. Gorolomova, S. Varbanov, T. Tosheva, G. Gencheva, A SERIES OF Zn2+ COMPLEXES OF 1,2-BIS(DIMETHYLPHOSPHINYLMETHYLENOXY)BENZENE LIGAND - SYNTHESIS, STRUCTURAL CHARACTERIZATION AND SOLUTION CHEMISTRY, Fifth National Crystallographic Symposium with International Participation, 25-27 September 2014, Bulgaria, University of chemical technology and metallurgy, Sofia.
  • Б. Георгиева, П. Гороломова, Г. Генчева, Определяне на стандартни окислително-редукционни потенциали на смесено валентни платинови комплекси, XIV национална конференция по Химия за студенти и докторанти, 20-22 май 2015, София, България, стр. 55.
  • P. Gorolomova, V. Velcheva, A. Tadjer,G. Gencheva*, Solid state structure of the ligand 2,2’-diaminopyridine– A combined theoretical and experimental study, Introduction to the theoretical background of the Rietveld method and principles of crystal structure refinement from powder diffraction data. Sofia, Bulgaria, 28 September - 3 October 2015.
  • P. Gorolomova, V. Velcheva, G. Gencheva, Experimental and Theoretical Study on the Molecular and Electronic Structure, Spectroscopic Properties and Coordination Behaviour of the Ligand 2,2-dipyridylamine, Sixth National Crystallographic Symposium with International Participation, Bulgarian Academy of sciences, Sofia, Bulgaria, 05-07.10. 2016, p. 49
  • P. Gorolomova, R.Petrova, B. Shivachev, S. Simova, G. Momekov, G. Gencheva, New AuIII-complexes with 2,2’-dipyridylamine. A quantum-chemical and experimental study of structure, spectroscopic properties and In Vitro antiproliferative effects , Young Research Fellow Meeting, Faculty of Pharmacy, University of Paris-South, Paris, France, 08-10 02 2017.