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Assos. prof. Ivayla Pantcheva, PhD

Ivayla Pantcheva

Phone: +3592-8161446;

E-mail: IPancheva@chem.uni-sofia.bg

Website: http://www.chem.uni-sofia.bg/depart/lbbc/BBC_core/index.html


Laboratory Members

Prof. Mariana Mitewa, D.Sc.

Assos. prof. Anife Ahmedova, PhD


Assos. prof. Juliana Ivanova, PhD


Assist. Prof. Vasil Atanasov, PhD (assoc. prof. at Military Medical Academy – Sofia)


Assist. Prof. Silviya Stoykova, PhD (assist. prof. at Military Medical Academy – Sofia)


Assist. Prof. Ivo Ivanov, PhD


Radoslava Dimitrova, PhD student



Research Topics

  • Coordination compounds of biologically active ligands (drugs, antibiotics, enzyme inhibitors, etc.): synthesis and structural characterization
  • Coordination properties and application of macrocyclic compounds (crown ethers and calixarenes)
  • Biochemical toxicology and toxins (influence of metal ions / metal complexes on different enzymes; in vitro and in vivo studies on toxicity and detoxification properties of metal complexes; snake venom toxins – hemotoxins, toxicity of phospholipase A2)
  • Analytical toxicology (analytical procedures and instrumental chromatographic methods for analyses of drugs and poisons in different matrices)
  • Application of instrumental chromatographic methods and mass-spectrometry for analyses of biologically active compounds
  • Theoretical (quantum-chemical) methods for structure and property description of the studied compounds (ligands and complexes)

Project Activity – (Research Projects in the last 5 years)

Projects financed by the Fund for Scientific Research

  • “Achievement of optimal environment for education, research, innovation and sustainable development of the human source in the field of chemical sciences: Adaptation of the today education for tomorrow” BG05M2OP001-2.009-0028, supervisor– Assoc. prof. Ivayla Pantcheva
  • New metal complexes: assessment of their potential for chelation therapy and targeted visualization of tumors and tumor affected lymph nodes by magnetic resonance imaging (MRI), supervisor– Assoc. prof. Juliana Ivanova (2019-)
  • New generation of supramolecular systems for enhancement of antitumour activity, supervisor– Assoc. prof. Anife Ahmedova (2014 - 2019)
  • New horizons for natural ionophorous antibiotics (Horizons & Ionophores), supervisor– Assoc. prof. Ivayla Pantcheva (2018 - )

Research Cooperation

International cooperation

  • Prof. K. Osakada, Tokyo Institute of Technology, Tokyo, Japan
  • Prof. Akita, Prof. Yoshizawa, Tokyo Institute of Technology, Tokyo, Japan
  • Prof. Y. Nishihara, Okayama University, Okayama, Japan
  • Prof. Wawer, Medical University Warsaw, Faculty of Pharmacy, Warsaw, Poland
  • Assoc. Prof. B. Gyurcsik, University of Szeged, Szeged, Hungary
  • Assoc. Prof. Snežana Ðordević, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia.
  • Assistant professor Dr. Irena Pashkunova-Martic, Medical University of Vienna, Austria

National cooperation

  • Prof. Georgi Momekov, PhD; assos. prof. Denitza Momekova, PhD - Faculty of Pharmacy, Medical University Sofia
  • Assos. prof. Pavlina Gateva – Faculty of Medicine, Medical University of Sofia
  • Prof. Svetlana Simova, D. Sc.; Assos. prof. Pavleta Shestakova, PhD; Assos. prof. Liudmil Antonov – Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences
  • Assos. prof. Radostina Alexandrova, PhD; assos. prof. Yordanka Gluhcheva, PhD; Assoc. Prof. Emilia Petrova, PhD; Assoc. Prof. Ekaterina Pavlova, PhD; Assoc. Prof. Ivo Vladov, PhD – Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences

Publications from the last 5 years

Nedzhib, А., J. Kessler, P. Bour*, B. Gyurcsik, I. Pantcheva*, Circular dichroism is sensitive to monovalent cation binding in Monensin complexes, Chirality 28(5) (2016) 420-428 https://DOI:10.1002/chir.22597

S. Stoykova*, K. Kanev, I. Pantcheva, V. Atanasov, Isolation and Characterization of Drugs of Abuse in Oral Fluid by a Novel Preconcentration Protocol, Anal. Lett. 49(17) (2016) 2822-2832 https://doi.org/10.1080/00032719.2016.1155594

S. Stoykova*, I. Pantcheva, K. Kanev, V. Atanasov, Confirmatory and comparative drug analysis of oral fluid and blood samples from drivers suspected of DUID, MD – Medical Data 8(1) (2016) 011-015.

Nedzhib, А., S. Stoykova, I. Samnaliev, L. Antonov, I. Pantcheva, Complexation of Pralidoxime (2-PAM) with Pd(II) and Pt(II), Military Med. 4 (2016) 55-60 (in Bulgarian)

Ivanova, Ju.*, Y. Gluhcheva, D. Dimova, E. Pavlova, S. Arpadjan, Comparative assessment of the effects of monensin and salinomycin on biodistribution of lead and some essential metal ions in mice, subjected to subacute lead intoxication, J Trace Elem. Med. Biol. 33 (2016) 31-36. https://doi.org/10.1016/j.jtemb.2015.08.003.

Tinkov, A. A.*, T. Filippini, O. P. Ajsuvakova, J. Aaseth, Y. G. Gluhcheva, Ju. M. Ivanova, G. Bjorklund, M. G. Skalnaya, E. R. Gatiatulina, E. V. Popova, O. N. Nemereshina, M. Vinceti, A. V. Skalny, The role of cadmium in obesity and diabetes. Review., Sci Total Environ 601-602 (2017) 741-745. https://doi.org/10.1016/j.scitotenv.2017.05.224.

Pantcheva, I., A. Nedzhib, L. Antonov, Oxime-containing acetylcholinesterase reactivators and their complexes with Pd(II) and Pt(II) ions - recent developments, Turk. J. Chem. 42 (2018) 418-

Stoykova, S.*, T. Kiryakova, D. Nikolov, A. Nedzhib, I. Pantcheva, V. Atanasov, Self-administrated propofol – a case report of a physician suicide, Toxicol. Anal. Clin. 30(2) (2018) 142-148 https://doi.org/10.1016/j.toxac.2018.03.002 (Q4)

Kircheva, V., D. Josifov, M. Milanova*, I. Pantcheva, J. Zaharieva, M. Nedyalkova, S. Konstantinov, V. Simeonov, I. Manolov, Assessment of Toxicity Issues of Bis-Coumarine Derivates and their Lanthanoid Complexes by Statistical Data Analysis, Biomed J Sci Tech Res. 9(4) (2018) https://DOI:10.26717/BJSTR.2018.09.001843

Pantcheva, I., M. Nedyalkova, P. Petkov, H. Aleksandrov, V. Simeonov*, Adaptation of the Education to the Day After, Khimiya (Chemistry – Bulg J. Sci. Edu.), 27(2) (2018) 197-207 (in Bulgarian)

Dyakova, L. V., T. Zhivkova, M. Georgieva, G. Miloshev, R. Kalfin, R. Tudose, G. Marinescu, I. Pantcheva, E.-M. Mosoarca, D.-C. Culita, L. Patron, O. Costisor, R. Alexandrova, Ni(II) complexes with different ligands express various degree of cytotoxicity, Toxicology Lett. 295(S1) (2018) S253 - ABSTRACTS of the 54th Congress of the European Societies of Toxicology (EUROTOX 2018) TOXICOLOGY OUT OF THE BOX Brussels, Belgium, 2nd – 5th of September, 2018

Abudalleh, A., Dinev, D., Zhivkova, T., Georgieva, M., Miloshev, G., Pantcheva, I., Miteva, M., Marinescu, G., Culita, D., Patron, L., Tudose, R., Costisor, O., Alexandrova, R., Cobalt(II) complexes with various ligands express different cytotoxic activity, FEBS Open Bio 8(S1) (2018) 322 – Abstracts of the 43rd FEBS Congress, Prague, Czech Republic, 7-12 July 2018

Tinkov, A. A.*, O. P. Ajsuvakova, J. Aaseth, Y. G. Gluhcheva, Ju. Ivanova, G. Bjorklund, M. Skalnaya, O. Skalnaya, A. V. Skalny, Toxic mechanisms of cadmium on life activities, J Environ. Occup. Med. 35(5) (2018) 470-480.

Gluhcheva, Y., K. Kamenova, P. Dorkov, Yu. Lobanova, M. Skalnaya, Ju. Ivanova*, Effects of meso-2,3-dimercaptosuccinic acid, monensin and salinomycin on the concentrations of cadmium and some essential elements in skeletal muscles of Cd-exposed mice, J Trace Elem. Med. Biol. 50 (2018) 596-600. https://doi.org/10.1016/j.jtemb.2018.04.015.

Kamenova, K., Y. Gluhcheva, S. Stoykova, I. Vladov, Ju. Ivanova*, Ameliorative effect of the anticancer agent salinomycin on cadmium-induced hepatotoxicity and renal dysfunction in mice, Environ. Sci. Pollut. Res. Int. 25(4) (2018) 3616-3627. https://doi.org/10.1007/s11356-017-0755-y.

Pantcheva, I., M. Nedyalkova, H. Alexandrov, P. Petkov (Eds.), International Scientific Conference „Chemistry Today for Tomorrow“, Book of Abstracts, St. Kliment Ohridski University Press, 2019, ISBN 978-954-07-4584-8.

Ivanov, I. D.*, S. S. Stoykova, N. T. Burdzhiev, I. N. Pantcheva, V. N. Atanasov, Analytically confirmed synthetic cannabinoid 5F-ADB sprayed on „herbal mixture“, Bulg. Chem. Comm. (Special Issue) 51(D) (2019) 32-35

Ivanov, I. D.*, S. Stoykova, E. Ivanova, A. Vlahova, N. Burdzhuev, I. Pantcheva, V. N. Atanasov, A case of 5F-ADB / FUB-AMB abuse: drug-induced or drug-related death? Forensic Sci Intern. 297 (2019) 372-377 https://doi.org/10.1016/j.forsciint.2019.02.005

Pantcheva, I.*, R. Dimitrova, A. Nedzhib, P. Dorkov, R. Stoyanova, E. Zhecheva, Coordination compounds of polyether ionophore Monensin with gadolinium(III) ions, In: Nanoscience & Nanotechnology, vol. 19(1), 2019, pp. 40-46, Balabanova, E., Mileva, E. (Eds.)

Alexandrova, R. I., T. D. Zhivkova, D. Ivanov, B. D. Andonova-Lilova, L. V. Dyakova, I. N. Pantcheva*, P. Dorkov, Preliminary study on in vitro toxicity of Monensin complexes against chemically-induced rat tumor and bone marrow cells from the same tumor-bearing animals, Chem. Didact. Ecol. Metrol. (2020) submitted

Pantcheva, I.*, R. Dimitrova, V. Ivanova, A. Nedzhib, P. Dorkov, D. Dinev, R. Spasov, R. Alexandrova, Spectral properties and biological activity of La(III) and Nd(III) Monensinates, Open Chemistry 17 (2019) 1423-1434, https://doi.org/10.1515/chem-2019-0134

Kamenova, K., Y. Gluhcheva, P. Dorkov, Ju. Ivanova*, Comparative assessment of the effects of meso-2,3-dimercaptosuccinic acid and salinomycin on spleen function of cadmium-exposed mice, Environ. Sci. Poll. Res. Int., 26 (2019) 33304-33310. https://doi.org/10.1007/s11356-019-06473-4.

Pantcheva, I., M. Nedyalkova, S. Kirilova, P. Petkov, V. Simeonov, Principles of the career development of the young scientist, Chemistry - Bulg J Sci Edu 28(3) (2019) 287-294 (in Bulgarian)

Pantcheva, I.*, A. Nedzhib, L. Antonov, B. Gyurcsik*, P. Dorkov, New insights into coordination chemistry of Monensin towards divalent metal ions, Inorg. Chim. Acta 505 (2020) 119481. https://doi.org/10.1016/j.ica.2020.119481

Dudev, T.*, D. Cheshmedzhieva, R. Dimitrova, P. Dorkov, I. Pantcheva*, Factors governing the competition between group IA and IB cations for Monensin A: a DFT/PCM study, RSC Advances 10 (2020) 5734-5741 https://doi.org/10.1039/C9RA09784H

Petrova, E. *, Y. Glucheva, E. Pavlova, I. Valdov, Ts. Voyslavov, Ju. Ivanova, Effect of acute sodium nitrite intoxication on some essential biometals in mouse spleen, J. Trace Elem. Med. Biol. 58 (2020) https://doi.org/10.1016/j.jtemb.2019.126431.

Ivanova, Ju., K. Kamenova, E. Petrova*, I. Valdov, Y. Gluhcheva, P. Dorkov, Comparative study on the effects of salinomycin, monensin and meso-2,3dimercaptosuccinic acid on the concentrations of lead, calcium, copper, iron and zinc in lungs and heart in lead-exposed mice, J Trace Elem. Med. Biol. 58 (2020) https://doi.org/10.1016/j.jtemb.2019.126429.

Teaching Activity

M. Sc. Program in Bioanalytical and Bioinorganic Chemistry

Lecturer Discipline Specialty
Assos. prof. A. Ahmedova Bioinorganic chemistry Ecochemistry (IV semester)
Assos. prof. A. Ahmedova Biocoordination chemistry Biology and Chemistry
(VII semester)
Assoc. prof. I. Pantcheva Analytical chemistry

Biology (II semester)

Biology and Chemistry
(II, III semester)

Pharmacy (III, IV semester)

Assist. prof. V. Atanasov Analytical toxicology Elective course
Assos. prof. J. Ivanova Macrocyclic and Supramolecular Chemistry – analytical and bio-aspects Elective course
Assoc. prof. A. Ahmedova Photochemistry Elective course
Assos. prof. A. Ahmedova / Assos. prof. I. Pantcheva Coordination compounds in medicine, Coordination compounds and their application in advanced technology Elective courses

Former PhD and Research Students


Ahmed Nedzhib (graduated in 2016) – supervisor I. Pantcheva

Silviya Stoykova (graduated in 2016) – supervisor V. Atanasov

Kalina Kamenova (graduated in 2018) – supervisor J. Ivanova

Ivo Ivanov (graduated in 2019) – supervisor I. Pantcheva / V. Atanasov

Yana Goranova (graduated in 2019) – supervisor V. Atanasov

M. Sc. students

Maxim Neshev (graduated in 2016) – supervisor V. Atanasov

Veneta Ivanova (graduated in 2018) – supervisor I. Pantcheva

B. Sc. students

Gemma Tolosa, Spain (graduated in 2016) – supervisor I. Pantcheva

Luis Guiu, Spain (graduated in 2016) – supervisor I. Pantcheva

Венета Иванова (graduated in 2016) – supervisor I. Pantcheva

Andrea Domec, Испания (graduated in 2020) – supervisor I. Pantcheva