| Head of the Laboratory Phone: +3592-8161208/347/394; E-mail: ggencheva@chem.uni-sofia.bg
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Laboratory Members (Including students and Ph.D students)
Assistant Professor Daniela Tsekova, PhD, Ultraviolet and Visible Absorption Spectroscopy, Electron Spin Resonance, Nuclear Magnetic Resonance, Magnetic Measurements;
Specialist-Chemist Sonia Zareva, PhD, Infrared Spectroscopy, Ultraviolet and Visible Absorption Spectroscopy, X-ray Diffraction Analysis;
Specialist-Chemist Paulina Gorolomova, PhD, Theoretical Methods and Quantum Chemical Calculations, Nuclear Magnetic Resonance;
Assistant Professor Vyara Velcheva, PhD, Single Crystal X-Ray Analysis, Biological Tests;
Research Topics
- Application of instrumental methods (UV/Vis, IR, Raman, EPR, NMR, Single Crystal X-ray Analysis, XPS) for structural and quantitative analysis;
- Synthesis, structure, and properties of coordination compounds designed as new materials and drugs;
- Quantum-chemical modeling of structure, spectral characteristics, and reactivity of ligands and theoretically predicted and experimentally synthesized complexes.
Project Activity
- National Science Fund, DN09/2016-2020: Rational Design of New Metal-Based Antitumor Agents.
- Sofia University “St. Kliment Ohridski”, Competition for Publication, 80-10-99/2022, Platinum (IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates. (Pharmaceutics 2022, 14, 2057). Sofia University “St. Kliment Ohridski”
- Sofia University “St. Kliment Ohridski”, Thematic Competition, 80-10-167/2024, Synthesis and structure of complexes of Pt(IV) with mono-, di- and tricarbamate forms of the ligand 2,4,6-triaminocyclohexane-1,3,5-triol (taci).
- European Union-Next Generation EU. National Recovery and Resilience Plan of the Republic of Bulgaria, No.70-123-662/2024
Research Cooperation
- Prof. Dr. Dr.h.c. Bernt Krebs, Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany: Single Crystal X-Ray Analysis, Platinum Cytotoxic Coordination Compounds;
- Prof. Dr. Kaspar Hegetschweiler, Univerisitaet des Saarlandes, Saarbruecken, Germany – Synthesis, structural characterization, and physicochemical properties of coordination compounds of the platinum group ions.
- Angel Ugrinov, Department of Chemistry and Biochemistry, North Dakota State University, United States – Structural Analysis.
Selected Publications
- V. Velcheva, K. Hegetschweiler, G. Momekov, S. Ivanova, A. Ugrinov, B. Morgenstern, G. Gencheva: Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates, Pharmaceutics, 14, 2057, 2022. https://doi.org/10.3390/pharmaceutics14102057
- G. Momekov, I. Ugrinova, E. Pasheva, D. Tsekova, G. Gencheva: Cellular Pharmacology of Palladinum(III) Hematoporphyrin IX Complexes: Solution Stability, Antineoplastic and Apoptogenic Activity, DNA Binding, and Processing of DNA-Adducts”, Int. J. Mol. Sci., 19, 2451, 2018. https://doi.org/10.3390/ijms19082451.
- V. Velcheva, K. Hegetschweiler, G. Gencheva: Crystal structure of all-cis-2,4,6-trihydroxycyclohexane- 1,3,5triaminium chloride sulfate, C6H18ClN3O7S, Zeitschrift fur Kristallographie - New Crystal Structures, 236, 1319, 2021. https://doi.org/10.1515/ncrs-2021-0324.
- M. Georgieva, Z. Gospodinova, M. Keremidarska-Markova, T. Kamenska, G. Gencheva, N. Krasteva: PEGylated nanographene oxide in combination with near-infrared laserirradiation as a smart nanocarrier in colon cancer targeted therapy, Pharmaceutics, 13, 424, 2021. https://doi.орг/10.3390/pharmaceutics13030424.
- Zh. V. Georgieva, A. G. Ugrinov, R. P. Nikolova, B. L. Shivachev, S. Y. Zareva, S. G. Varbanov, T. D. Tosheva, G. G. Gencheva: Coordination of bis((dimethylphosphinyl) methyl)amine to copper(II). Synthesis and single-crystal structure of its mononuclear octahedral copper(II) complex, Bulgarian Chemical Communications, J50, 251, 2018.
Teaching Activity
| Lecture | Discipline | Specialty |
| Prof. G. Gencheva | Instrumental Methods for Analysis 2 | Bachelor’s Degree Programmes: Chemistry, Eco Chemistry, Nuclear Chemistry |
| Assist. Prof. D. Tsekova | Analytical Chemistry and Instrumental Analysis 1 | Bachelor’s Degree Programmes: Chemistry and Informatics, Chemistry and English, Biology and Chemistry |
| Assist. Prof. D. Tsekova | Analytica Chemistry 1 & 2 | Bachelor’s Degree Programme: Chemistry |
| Prof. G. Gencheva | Analytical Chemistry and Instrumental Analysis 2 | Bachelor’s Degree Programmes: Chemistry and Informatics, Chemistry and English, Biology and Chemistry |
| Prof. G. Gencheva | Vibrational Spectroscopy – Methods and Application | Bachelor’s Degree Programmes |
| Prof. G. Gencheva | Modern Methods in Molecular Spectroscopy | Master’s Degree Programme: Modern Spectral and Chromatographic Analytical Methods |
| Prof. G. Gencheva | Modern Applications of Molecular Spectroscopy in Chemical Analysis | Master’s Degree Programme: Smart Analytics |
| Prof. G. Gencheva | Infrared and Raman Spectroscopy | Master’s Degree Programme: Modern Spectral and Chromatographic Analytical Methods |
| Prof. G. Gencheva | Ultraviolet and Visible Absorption Spectroscopy and Molecular Fluorescence | Master’s Degree Programme: Modern Spectral and Chromatographic Analytical Methods |
| Prof. G. Gencheva | Electrochemical methods of analysis | Master’s Degree Programme Bachelor’s Degree Programmes |
PhD defended
Daniela Tsekova
Sonya Zareva
Paulina Gorolomova
Vyara Velcheva
Defended Graduates
Master’s Degree
Vyara Velcheva
Mirela Vrajilova
Borislava Georgieva
Bachelor’s Degree
Marianna Vassilaki
Vyara Velcheva
Mirela Vrajilova
Suzana Taindjieva
PhD Students
Mirela Vrajilova
Borislava Georgieva