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Phone: (+359 2) 8167 311
E-mail: hgagov@abv.bg


Department of Human and Animal Physiology,

Faculty of Biology, Sofia University ‘St. Kliment Ohridski’,

8 Dragan Tzankov blvd., 1164 Sofia

Degrees 2012 - Professor, Sofia University "St. Kliment Ohridski"
Teaching activities in Bachelor degree Lectures in Human physiology and in Animal and human physiology
Teaching activities in Master degree Lectures and seminars in Physiology of excitable cells and in Nerve cell
Other activities and responsibilities

Head of Department of Animal and Human Physiology, Head of Laboratory of Excitable Cells, Vice-dean of International and Scientific Affairs, and of PhD Students

Cell signaling; Smooth muscle cells; Adipose tissue; Patch clamp method; Myography; Fluorescence; Hormones; Heart physiology and regulation; Diabetes; Aging; Metal and carbon nanoparticles; Gas mediators: NO, H2S, CO; Ca2+ sensitization/desensitization.

Research interests  
Selected publications  

1. Emilova, R., Dimitrova, D., Mladenov, M., Daneva, T., Schubert, R., Gagov, H. 2014. Cystathionine gamma-lyase of perivascular adipose tissue with reversed regulatory effect in diabetic rat artery. Biotechnol Biotechnol Eq. (in press). DOI:10.1080/13102818.2014.991565

2. Lech, A., Daneva, T., Pashova, S., Gagov, H., Crayton, R., Kukwa, W., Czarnecka, A.M., Szczylik, C. (2013) Ovarian cancer as a genetic disease. Front Biosci. 18 (2): 543-563.

3. Olga Zavaritskaya, Nadezda Voblova, Johanna Schleifenbaum, Torsten Gloe, Reinhard Kluge, Mitko Mladenov, Hristo Gagov, Gabor Fesüs, Christopher S. Crean, Maik Gollasch, Rudolf Schubert. (2013) Vascular and antihypertensive effects of synthetic KCNQ channel openers in spontaneously hypertensive rats and New Zealand obese mice. Hypertension. 61: 151-159.

4. Loukanov AR, Gagov H. (2012) High-resolution subunit detection of glutamate receptor by ultrasmall gold nanoparticles. Microsc Res Tech. 75(9): 1159-1164.

5. Dimitrova DZ, Dimitrov SD, Iliev I, Mladenov MI, Hristov KL, Mihov DN, Duridanova DB, Gagov H.S. (2010) Ghrelin signaling in human mesenteric arteries. J. Physiol. Pharmacol. 61 (4): 383-390.

6. Sazdova I, Ilieva B, Minkov I, Schubert R, Gagov H. (2009) Obestatin as contractile mediator of excised frog heart. Cen Eur J Biol. 4(3): 327-334.

7. Mladenov MI, Hristov KL, Dimitrova DZ, Schubert R, Lubomirov LT, Gjorgoski IK, Duridanova DB, Gagov HS. (2008) Ghrelin signalling in guinea-pig femoral artery smooth muscle cells. Acta Physiol (Oxf). 94: 195-206.

8. Ivanova IV, Schubert R, Duridanova DB, Bolton TB, Lubomirov LT, Gagov HS. (2007) Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog. Exp Physiol. 92: 1037-1046.

9. Pfitzer G, Lubomirov LT, Reimann K, Gagov H, Schubert R (2006) Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling. J Muscle Res Cell Motil. 27(5-7): 445-54. IF 2.214

10. Lubomirov L, K Reimann, D Metzler, V Hasse, R Stehle, M Ito, H Gagov, G Pfitzer, R Schubert (2006) Urocortin-induced decrease in Ca2+-sensitivity of mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase. Circ Res. 98(9): 1159-67.

11. DB Duridanova, Gagov HS, Bolton TB (2005) HO-1 induction in the guinea-pig stomach: protection of smooth muscle functional performance during cobalt-induced oxidative stress. Cell Moll Biol. 51: 495-506.

12. K Hristov, I Altankova, H Gagov, T Bolton, KK Boev, D Duridanova (2004) Calcium-dependent changes in potassium currents in guinea-pig coronary artery smooth muscle cells after acute cobalt loading in vivo. Pflugers Arch. 449(1): 16-25.

13. R. Schubert; U. Krien; I. Wulfsen; D. Schiemann; G. Lehmann; N. Ulfig; R. Veh; J. Schwarz, H. Gagov (2004) Nitric oxide donor sodium nitroprusside dilates rat small arteries by activation of inward rectifier potassium channels. Hypertension 43(4): 891-6.

14. H. Gagov, B. Kadinov, K. Hristov, K. Boev, D. Itzev, T. Bolton, D. Duridanova (2003) Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone. Pflugers Arch. 446(4): 412-21. IF 2.352

15. B. Kadinov, D. Itzev, H. Gagov, T. Christova, T. Bolton, D. Duridanova (2002) Induction of heme oxygenase in guinea-pig stomach: roles in contraction and in single muscle cell ionic currents. Acta Physiol. Scand. 175: 297-313.

16. L. Lubomirov, H. Gagov, P. Petkova-Kirova, D. Duridanova, V. Kalentchuk, R. Schubert (2001) Urocortin relaxes rat tail arteries by a PKA-mediated reduction of sensitivity of the contractile apparatus for calcium. Br. J. Pharmacol. 134: 1564-1570.

17. G.V. Petkov, F. Fusi, S. Saponara, H.S. Gagov, G.P. Sgaragli, K.K. Boev (2001) Characterization of plasma membrane calcium currents in freshly isolated smooth muscle cells from rat tail main artery. Acta Physiol. Scand. 173: 1-9.

18. F. Fusi, S. Saponara, H. Gagov, G. Sgaragli (2001) 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation. Br. J. Pharmacol. 133: 988-996. IF

19. F. Fusi, S. Saponara, H. Gagov, G. Sgaragli (2001) Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea-pig gastric fundus smooth muscle cells. Br. J. Pharmacol. 132: 1326-1332.

20. R. Schubert, U. Krien, H. Gagov (2001) Protons Inhibit the BKCa Channel of Rat Small Artery Smooth Muscle Cells. J. Vascular Res., 38: 30-38.

21. P.S. Petkova-Kirova, H. Gagov, U. Krien, D. Duridanova, T. Noack, R. Schubert (2000) 4-Aminopyridine affects rat arterial smooth muscle BKCa currents by changing intracellular pH. Br. J. Pharmacol., 131: 1643-1650.

22. D.B. Duridanova, P.S. Petkova-Kirova, L.T. Lubomirov, H. Gagov, K.K. Boev (1999) Corticotropin-releasing hormone acts on guinea-pig ileal smooth muscle via protein kinase A. Pflugers Arch. 438 (2): 205-212.

23. D. B. Duridanova, H.S. Gagov, K.K. Boev (1997) Two populations of smooth muscle cells from the guinea-pig gastric antrum. Eur. J. Pharmacol. 331: 105-111.

24. D.B. Duridanova, H.S. Gagov, S.V. Dimitrov, K.K. Boev (1997) Main components of voltage-sensitive K+ currents in the human colonic smooth muscle cells. Digestion 58: 479-489.

25. D.B. Duridanova, M.D. Nedelcheva, H.S. Gagov (1997) Oxytocin-induced changes in single cell K+ currents and smooth muscle contraction of the guinea-pig gastric antrum. Eur. J. Endocrinol. 136: 531-538.

26. D.B. Duridanova, H.S. Gagov, K. K. Boev (1996) Calcium-induced Ca2+ release activates potassium currents by cyclic GMP-dependent mechanism in single gastric smooth muscle cells. Eur. J. Pharmacol. 298: 159-163.

27. H. Gagov, D. Duridanova, K. Boev (1993) Inhibition of calcium current in ileal cells by cyclopiazonic acid and ryanodine. Eur. J. Pharmacol. 243: 19-24.


Member of the Bulgarian Physiological Society

Editor in Chief of Book №3 of Annuaire de l’Universite de Sofia, Faculty of Biology