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Silviya Stoykova

Email: sstoykova@chem.uni-sofia.bg

Phone: +359 2 8161609

Cabinet / laboratory: 220, 221

Sofia University „St. Kliment Ohridski”

Faculty of Chemistry and Pharmacy

1164 Sofia, 1 James Bourchier Blivd.

Education

  • B. Sc. – specialty “Computer Chemistry”, SU “St. Kliment Ohridski”
  • M. Sc. – specialty “Medicinal Chemistry”, SU “St. Kliment Ohridski”
  • Ph. D. – Chemical sciences (Analytical chemistry), SU “St. Kliment Ohridski”
  • specialist in toxicology – acquired specialty in “Toxicology”, Medical University - Sofia

Professional Experience

  • assistant (Military toxicology), Military medical academy – Sofia, 06.02.2013 – 30.07.016
  • chemist (Forensic toxicology), Military medical academy – Sofia, 01.08.2016 – present
  • head assistant professor (Analytical chemistry), Sofia university “St. Kliment Ohridski”, 01.07.2016 – present

Research Interests

  • analytical /forensic/ toxicology and its application in clinical and medico-legal practice - analysis of drugs and toxic substances in various biological samples (blood, urine, etc.), as in alternative matrices (e.g., oral fluid); expert activity
  • analysis of new psychoactive drugs in biological samples
  • forensic analysis of toxic substances in various biological matrices; screening methods
  • bioanalytical chemistry - biochemical methods for analysis
  • toxins in the venom of the Bulgarian nose-horned viper – vipoxin, phospholipase A2, vipoxin acidic component (VAC)

Selected Publications (max 5)

  1. Stoykova S, Kiryakova T, Nikolov D, Nedzhib A, Pantcheva I, Atanasov V. Self-administrated propofol – a case report of a physician suicide. Toxicologie Analytique et Clinique 2018; 30: 142-148. DOI: 10.1016/j.toxac.2018.03.002
  2. Ivanov I, Stoykova S, Ivanova E, Vlahova A, Burdzhiev N, Pantcheva I, Atanasov V. A case of 5F-ADB / FUB-AMB abuse: drug-induced or drug-related death? Forensic Science International 2019; 297: 372-377. DOI: 10.1016/j.forsciint.2019.02.005
  3. Ahmedova A, Mihaylova R, Stoykova S, Mihaylova V, Paunova-Krasteva T, Mihaylov L, Stoitsova S, Nihtianova D, Momekov G, Momekova D, Yoshizawa M. Enhanced cellular uptake of platinum by a tetracationic Pt(II) nanocapsule and its implications to cancer treatment. European Journal of Pharmaceutical Sciences 2020; 155: 105545. DOI: 10.1016/j.ejps.2020.105545
  4. Goranova Y, Stoykova S, Samnaliev I, Atanasov V. Effect of Vipoxin (V. amm. meridionalis) and its components on neuromuscular transmission. Interdisciplinary Toxicology (Interdiscip toxicol) 2020; 13(1): 21-27. DOI: 10.2478/intox-2020-0003
  5. Ivanov ID, Stoykova SS, Burdzhiev NT, Pantcheva IN, Atanasov VN. Synthetic Cannabinoids 5F-QUPIC and MDMB-CHMICA in Plant Material – Identification and Quantification by Gas Chromatography – Mass Spectrometry (GC-MS), Nuclear Magnetic Resonance (NMR), and High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD). Analytical Letters 2021; 54(16): 2600-2610. DOI: 10.1080/00032719.2021.1879109

List of Publications

Project Activity – (Research Projects in the last 5 years)

  • Analysis of "herbal mixtures" containing synthetic cannabinoids applied, Research Fund of Sofia University "St. Kliment Ohridski ", manager, contract number: 80-10-23, 2018
  • Comparative study of the potential application of new chelating agents as antidotes in lead intoxication, Research Fund of Sofia University “St. Kliment Ohridski ", member of the research team, contract number: 80-10-168, 2018.
  • New horizons for natural ionophore antibiotics, Ministry of Education and Science Research Fund, member of the research team, contract number: KP-06-H29/3, 2018.
  • New bimodal imaging sensors, Ministry of Education and Science Research Fund, member of the research team, contract number: KP-06-H29/12, 2018.
  • In vivo study of the effect of chelating agents on the inflammatory cytokines TNF alpha, IL-1 beta and IL-6 in acute lead poisoning, Research Fund of Sofia University “St. Kliment Ohridski ", member of the research team, contract number: 80-10-131, 2019
  • New metal complexes: evaluation of their potential for chelation therapy and targeted imaging of tumors and tumor-affected lymph nodes by magnetic resonance imaging (MRI), Ministry of Education and Science Research Fund, member of the research team, contract number: KP-06-Austria-6, 2019
  • Synthesis and pharmacological evaluation of new platinum complexes with antitumor activity in the nanomolar concentration range, Research Fund of Sofia University “St. Kliment Ohridski ", member of the research team, contract number: 80-10-236, 2020
  • Investigation of the coordination ability of the macrolide antibiotic Tilmicosin, Research Fund of Sofia University “St. Kliment Ohridski ", manager, contract number: 80-10-143, 2021
  • Synthesis and pharmacological evaluation of the antitumor activity of a new class of platinum complexes, Ministry of Education and Science Research Fund, member of the research team, contract number: KP-06-H-59/9, 2021
  • Evaluation of the activity of polyether ionophores and their metal derivatives against Human Herpes Viruses (HHVs), Research Fund of Sofia University “St. Kliment Ohridski ", manager, contract number: 80-10-168, 2022

Teaching Activity

Period from - to Discipline Specialty
2013 - present Analytical toxicology

Medicinal chemistry;

Chemistry;

Computer chemistry;

Chemical engineering and contemporary materials;

Nuclear chemistry;

Ecochemistry

2014 Analytical chemistry Molecular biology
2015 - present Forensic Toxicology Pharmacy
2016 - present Analytical chemistry Pharmacy
2016 - present Toxicology Pharmacy

External Scientific Service Activities

Membership in scientific societies:

  • The International Association of Forensic Toxicologists (TIAFT)
  • Bulgarian Society of Clinical Toxicology (BgClinTox)
  • Balkan Academy of Forensic Sciences (BAFS)

Reviewer of Manuscripts for:

  • Bulgarian Chemical Communication
  • Journal of IMAB
  • Interdisciplinary toxicology