Head of the group
Prof. Dr. Tzvetanka Ivanova
Group members
Prof. DSc. Konstantin Balashev
Assist. Prof. Dr. Nikolay Grozev
Assist. Prof. Dr. Kristina Mircheva
Assist. Prof. Dr. Petar Georgiev
Dr Silvia Simeonova
PhD student Aleksandar Chanachev
Prof. DSc Ivan Panaiotov (Emeritus)
Prof. DSc Christian Vassilieff (Emeritus)
Research interests
Study of the state, electrical and rheological properties of the model 2D-systems: monolayers, liposomial bilayers and suspensions. Interfacial and temporal organization of the lipolysis. Mechanisms of degradation of the polyesters and lipid micro- and nano-capsules. Photochemical reactions at the interface. State, electrical and rheological properties of the biopolymer model monolayers from the plant kingdom. Atomic Force Microscopy (AFM).
International cooperation
Laboratory of Enzymology at Interfaces and Physiology of Lipolysis, CNRS, Marseilles, France
Laboratory of Particle Vectorisation, University of Angers, France
Laboratory of Enzyme Design, Novo Nordisk, Denmark
Nanoscience Center, University of Copenhagen, Denmark
Teaching activity
The Laboratory is engaged in the education of students from all academic levels
B. Sc. courses
Lectures and practical exercises in: physical chemistry and colloidal chemistry
M. Sc. courses
Master program: Biophysical Chemistry in Medicine and Pharmacology
Lectures and practical exercises in: Biophysical Chemistry, Colloidal dispersions in medicine and pharmacy
Master Thesis
PhD Thesis
Selected papers
I. Panaiotov, R. Verger, “Enzymatic reactions at the interface”, in Physical Chemistry of Biological Interfacers”
ed. by W. Norde and A. Baszkin, Elzevier (2000), 359.
C.Vassilieff, I.Panaiotov, E. D. Manev, J.E. Proust and Tz. Ivanova, “Kinetics of liposome disintegration from foam film studies: Effect of the lipid bilayer phase state” Biophysical Chemistry: 58 (1996) 97.
N.Grozev, V..Aguié-Béghin, Tz.Ivanova, S.Baumberger, B.Cathala, R.Douillard, I.Panaiotov,“State, electrical and rheological properties of model and dioxan isolated lignin films at the air-water interface” Coll. Polym. Sci., 280 (2002) 798.
I. Minkov, Tz. Ivanova, I. Panaiotov, J. Proust, P. Saulnier, “Reorganisation of lipid nanocapsules at air-water interface: 1. Kinetics of surface film formation” Colloids and Surfaces B: Biointerfaces, 45 (2004) 32.
K. Mircheva, I. Minkov, Tz. Ivanova, I. Panaiotov, J.E.Proust, R. Verger, “Comparative study of lipolysis by PLA2 of DOPC substrates organized as monolayers, bilayer vesicles and nanocapsules”,Colloids and Surfaces B:Biointerfaces, 67 (2008) 107.
K. Mircheva, Tz. Ivanova, I. Panaiotov, V. Dusel, F. Boury, “Enzymatic proteolysis of alfa gliadin monolayer spread at the air water interface”, J. Coll.Int. Sci., 347 (2010) 69.
K. Mircheva, Tz. Ivanova, I. Panaiotov, R. Verger, ”Hydrolysis of mixed monomolecular films of tricaprylin/dilauroylphosphatidylcholine by lipase and phospholipase A2”, Colloids and Surfaces B: Biointerfaces , 86 (2011) 71.
K. Balashev, Tz.Ivanova, K. Mircheva, I.Panaiotov, „Savinase proteolysis of insulin Langmuir monolayers studied by surface pressure and surface potential measurements accompanied by atomic force microscopy (AFM) imaging” Journal of Colloid and Interface Science 360 (2) (2011) 654.
I. Minkov, K. Mircheva, N.Grozev, Tz. Ivanova, I. Panaiotov – Properties of mixed monolayers of clinical lung surfactant, serum albumin and hydrophilic polymers, Colloids and Surfaces B: Biointerfaces, 101 (2013) 135-142.
P. Georgiev, A. Bojinova, B. Kostova, D. Momekova, T. Bjornholm, K.Balashev, „Implementing atomic force microscopy (AFM) for studying kinetics of gold nano-particle's growth” Colloids Surf A: Physicochem Eng Aspects, 434 (2013) 154
K. Mircheva, M. Gonnet, K. Balashev, Tz. Ivanova, F. Boury, I. Panaiotov, “Properties of -carotene and retinoic acid in mixed monolayers with dipalmitoylphosphatidylcholine (DPPC) and Solutol”,Colloids and Surfaces A: Physicochem Eng Aspects, .460 (2014) 209.
Tz. Ivanova, K. Mircheva, K. Balashev, I. Minkov, P. Saulnier and I. Panaiotov, “Interfacial behavior of lipid nanocapsules spread on model membrane monolayers”, Coll. Polym. Sci, 292 (6) (2014) 1307.
A.C.Groo, K. Mircheva, J. Bejaud, C. Aihas, I.Panaiotov, P. Saulnier, Tz. Ivanova, F. Lagarce, - Development of 2D and 3D Mucus Models and Their Interactions with Mucus Penetrating Paclitaxel- loaded Lipid Nanocapsules, Pharmaceutical Research, 31 (7) (2014) 1753.