каб. 255
тел: (02) 8167 291
e-mail: r.konakchieva@biofac.uni-sofia.bg
| Служебен Адрес | СУ Св. „Кл. Охридски”, Биологически ф-т,
бул. „Драган Цанков” № 8, София-1164 |
| Заемана длъжност | Професор по биологически науки (Хистология) |
| Основни дейности и отговорности |
Лектор на основен курс по „Обща Хистология” за студенти от бакалавърска степен на обучение. Лектор на задължителен курс „Хормонален контрол на репродуктивната фиункция при бозайниците“ за студенти от МП Биология на развитието
Лектор на задължителен курс „Биология на развитието при бозайниците“ за студенти от МП Биология на развитието |
| Академичен опит | 1985 – 1989 - редовен докторант – ИБИР, БАН 1989 – 2000 – научен сътрудник II-I ст.- ИБИР, БАН
2001 - 2012 – хоноруван преподавател към катедра "Цитология, хистология и ембриология" 2016 – понастоящем – Ръкводотел Катедра Цитология, хистология и ембриология, Биологически факлтет |
| Образование, академични степени и звания | 1982 Диплом за висше образование, Биологически факултет, СУ „Св. Кл. Охридски”. Дипломна квалификация Специалист-Микробиолог. 1990 - Кандидат на биологическите науки (Доктор по биология) - ИБИР - БАН 2010 - Доктор на биологическите науки - ИБИР - БАН |
| Международни грантове | 1990 Institute of Animal Nutrition and Physiology, Polish Academy of Sciences,Warsaw, Poland. Радиоимунологични и радиорецепторни системи за количествено определяне на белтъчни и стероидни антигени и рецептори. Междуакадемичен обмен, БАН 1993-1994 Centre for Reproductive Biology, MRC Unit, Edinburgh, UK. Молекулярна невроендокринология. МААЕ, Виена 1996 Neuroadaptations Group, Max-Planck Institute of Psychiatry, Munich, Germany. Невробиология и неврофармакология на адреналната ендокринна ос. DAAD, Бон 1998-1999 Laboratory of Neurobiology and Circadian Rhythms, CNRS, Louis-Pasteur University, Strasbourg, France.Участие на епифизни хормони в регулаторните взаимодействия между невроендокринната и имунната система. CNRS, Париж 2000 Max-Planck Institute of Psychiatry; Max-Planck Institute of Neurobiology, Munich, Germany.Научни посещения. МААЕ, Виена 2001 Neuroadaptations Group, Max-Planck Institute of Psychiatry, Munich, Germany. Участие на кортикостероиди в диференцирането на имунна тъкан. Научно посещение. DAAD, Бон 2012 - Германия, Университет Йена, Лаборатория по изследване на плацентата FP7 –ReProForce |
| Ръководител на Научни проекти
| 2017- on Erasmus+ Capacity Building in Higher Education - EAC/A03/2016 586181-EPP-1-2017-1-RS-EPPKA2-CBHE-JP Curricula Development in the Fields of Reproductive Biology/Assisted Reproductive Technologies and Regenerative Medicine in Serbia; P4 Coordinator 2017 – on Research Infrastructure for Cell Technologies in Biomedicine, National Roadmap for Research Infrastructures 2017-2023, Coordinator 2013 – 2015 ESF/OP HR BG051PO001-3.3.06-0059 Fundamental training and practical training of PhD students, post-docs, specialists and young scientists in interdisciplinary biological disciplines and innovative biotechnologies Coordinator 2009 - 2013 FP7 REGPOT – 2009-1. ReProForce Grant. WP2 Leader Technological equipment of IBIR-BAS 2006 - 2010 National Science Fund of Bulgaria. Antioxidant role of melatonin in the idiopathic male infertility and varicocele 2001 – 2004 University of Skopje, Macedonia. Institute of Animal Husbandry. Stress and adaptation in farm animals. 1999 - 2001 R & D Division, Sopharma & University of Chemistry and Technology, Sofia. Comparative bioavailability studies of steroids in volunteers under different prescription regime. 1999 - 2002 National Science Fund of Bulgaria. Endocrine and immune correlates of impaired adrenocortical function in patients with active Cushing,s syndrome. 1997 - 1998 R & D Division, Jenapharm GmbH & Co. KG. In-vitro studies of steroidal effects on cytokine production by lymphoid cells. 1996 - 1998 National Science Fund of Bulgaria, Bulgaria. Pineal gland and the control of the HPA axis. 1992 – 1995 National Science Fund of Bulgaria, Bulgaria. Effect of melatonin on lymphoid cells function. |
| Организационни умения и компетенции |
Организиране на курсове и разработване на учебни програми Осигуряване на високо квалифицирани преподаватели за обучение на студентите от магистърските програми Организиране и координиране на мобилен обмен на студенти и преподаватели от катедрата образователни и научни Европейски програми Организиране и оборудване на учебни лаборатории и лаборатории за научни изследвания на преподаватели, докторанти и дипломанти. Организиране и провеждане на практически курсове, научни семинари Координиране подготовката на студентите от магистърските програми при разработване и защита на дипломните работи |
| Научни публикации | Дисертации и монографии 1. Конакчиева, Р. (1989) Роля на надбъбречните жлези в регулацията на половата цикличност при овце. Дисертация за кандидат на биологическите науки (БАН). 2. Конакчиева, Р. (2009) Мелатонин и пластичност на физиологични механизми контролиращи адаптацията. Дисертация за доктор на биологическите науки (БАН). 3. Конакчиева Р, Стефанова Н (2016) Обща Хистология, Учебник, Издателство на СУ Св. Кл. Охридски Избрани научни публикации в международни списания Marinova, C., Persengiev, S., Konakchieva, R., Ilieva, A., Patchev, V. (1991) Melatonin effects on glucocorticoid receptors in rat brain and pituitary:significance in adrenocortical regulation. Intern J Biochem 23:479-481. (IF= 3.82) Kanchev, L., Konakchieva, R., Angelova, P., Davidoff, M. (1995) Substance P modulating effect on the binding capacity of hamster Leydig cell LH receptors. Life Sciences 56: 1631-1637. (IF-2.35) Angelova PA, Kanchev LN, Davidoff MS and Konakchieva R. (1995). LH receptors in hamster Leydig cells: effect of Substance P. Exp Clin Cancer Res 14, Suppl. 90, 90-91. (IF-1.92) Konakchieva, R., Kyurkchiev, S., Kehayov, I., Taushanova, P., Kanchev, L. (1995) Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells. J. Neuroimmunol 63:125-132. (IF-3.64) Konakchieva, R., Mitev,Y., Almeida, OFX., Patchev, V. (1997) Chronic melatonin treatment and the HPA axis in the rat: Attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release. Biology of the Cell 89:587-596. (IF- 3.75) Konakchieva, R., Mitev, Y, Almeida, OFX, Patchev, V. (1998) Chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the hypothalamic-pituitary-adrenal axis in the rat. Neuroendocrinol 67:171-180. (IF-2.45) Konakchieva, R., Manchev, S., Pevet, P., Masson-Pevet, M. (1999) Autoradiographic detection of (125I)-iodomelatonin binding sites in immune tissue of rats. Adv Exp Med Biol series, 460:411-415, Plenum Press, NY. (IF-1.38) Таushanova P., Georgiev G, Manchev S, Konakchieva R. (2007) Localization and physiological significance of (125I)-iodomelatonin binding sites in immunne tissue of rats. Comptes Rendus de l, Academie des Sciences , 60:899-902 (IF=0.11) Stephanova E., Topouzova-Hristova T., Konakchieva R. (2008) Mitochondria are involved in stress response of A549 alveolar cells to halothane toxicity. Toxicology In Vitro, 22(3):688-694 (IF=2.05) Tomova A., Kumanov P., Robeva R., Manchev S., Konakchieva R. (2008) Melatonin secretion and non-specific immune responses are differentially expressed in corticotropin-dependent and corticotropin-independent Cushing’s syndrome. Med Sci Monitor 14(6): CR327-332. (IF= 1.59). Todorov P., Konakchieva R, Dimitrov Y., Novachkov V., Kyurkchiev D., Tchoob N., Gorohova N. (2006) Morphological and functional assessment of human fetal liver cells in long-term culture. Problems of Cryobiology, 16 (2): 201-206. Gjorgovska N, Filev K, Konakchieva R. (2008) Influence of induced molting on hormonal status of aged laying hens. Krmiva (Zagreb), 1; 19-25. Dineva J., Vangelov I., Nikolov G., Konakchieva R., Ivanova M. (2008) Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone by human granulose luteinized cells with an antiapoptotic effect. Endocrine Regulations, 42 (2-3):45-51. Todorov P., Hristova E., Konakchieva R., Michova A., Dimitrov Y. (2010) Comparative studies of different cryopreservation methods for mesenchymal stem cells derived from human fetal liver. Cell Biol. Int. 34: 455-462. (IF=1.62) Vachkova E, Penchev I, Georgiev B, Biviloarski B, Konakchieva R. (2010) Relationships between plasma concentrations of Epidermal Growth Factor, insulin and iodated thyroid hormones in early andnormal weaned rabbits. Revue Méd. Vét., 161, 1, 30-36. (IF=0.19) Vachkova Е, Bivolarski B, Gulubova M, Konakchieva R, Georgiev I, Simeonov R. (2011) Immunohistochemical localisation of EGF receptors in the intestinal tract of growing rabbits in relation to age. Livestock Science 142:216–221. (IF = 1.29) Konakchieva R, Todorov P. (2011) Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways. Fert Steril, 96: e159. (IF - 3.96) Dimitrov, R., Georgiev, G., Todorov, P., Dimitrov, Y., Konakchieva, R. (2012). Membrane melatonin receptor type MT1 expression in human ejaculated spermatozoa, Comptes Rendus de L'Academie Bulgare des Sciences 65 (7), 947-952. (IF = 0.204) Други: Конакчиева, Р. (2000). Пинеална жлеза и мелатонин, Обзор. Съвременна Медицина Год. LI, кн. 2, 25–29. Тодоров П., Конакчиева Р., Димитров Й., Стаменов Г. Преимплантационна генетична диагностика: съвременно състояние и перспективи. Акушерство и гинекология 2001, 41, 1: 32-33 Todorov P., Stamenov G., Todorov I., Novachkov V., Dimitrov Y, Konakchieva R. Evaluation of the secretory capacity of ovarian tissue after treatment with different cryoprotectants by in vitro culture system. Comptes rendus de l’Academie bulgare des Sciences 2002, 55, 3: 103-108. Todorov P., Konakchieva R., Stamenov G., Todorov I., Novachkov V., Dimitrov Y. In vitro stimulation of the secretion of 17-b –estradiol and progesterone in a primary ovarian cell culture. Comptes rendus de l’Academie bulgare des Sciences 2002, 55, 6: 111-115. Тодоров П., Конакчиева Р. Предимплантационна диагностика на хромозомни аберации и болести, свързани с пола, чрез флуоресцентна “ин ситу” хибридизация. Репродуктивно здраве, 2003, 2:10-13. Todorov P, Konakchieva R, Dimitrov J, Chub N, Petrenko Y. Vitrification of human embryonic stem cells for cryopreservation. Comptes rendus de l’Academie bulgare des Sciences 2005, 58, 9: 1095-1100. Тодоров П., Конакчиева Р., Димитров Й., Славчев Б., Новачков В Криоконсервация на човешка овариална тъкан – нашият опит. Ембриология 2006, 1: 4-8. Dineva J, Nikolov G, Vangelov I, Konakchieva R, Ivanova M. Apoptosis of human granulosa luteinized /GLC’s/ and cumulus cells /CCs in relation to age of women. Comptes rendus de l’Academie bulgare des Sciences 2004, 57, 8: 113-116 Тодоров П, Конакчиева Р, Димитров Й. Ефект на рекомбинантен FSH върху синтеза и секрецията на естрадиол-17 бета от човешки гранулозни клетки ин-витро. Ендокринология, 2005, X, 3:149-153. . Todorov P., Konakchieva R., Dimitrov J., Chub N., Petrenko Y. Vitrification of human embryonic stem cells. Comptes rendus de l’Academie bulgare des Sciences, 2005, 58, 9:1095-1100 Тодоров П., Конакчиева Р., Димитров Й., Славчев Б., Новачков В Криоконсервация на човешка овариална тъкан – нашият опит. Ембриология 2006, 1: 4-8 Георгиев Г., Конакчиева Р. Епигенетично моделиране на ембрионалното и постнаталното развитие. Ембриология 2007, 2, 1:16-20. |
| Участия в международни и национални форуми | Dilova V., Konakchieva R., Dilov P., Kanchev L., Kojucharov, E. Albumin microspheres as a drug delivery system for dexamethasone:pharmacokinetics in sheep and distribution in rats. 6th EAVPT Congress, Edinburgh, UK, 7-11 August 1994. (IF=0.78) Konakchieva, R, Patchev,V. Melatonin treatment counteracts stress-induced impairment in HPA regulation. Annual Institute Symposium, Max Planck Institute of Psychiatry, Munich, Germany, 17-18 July, 1996. Konakchieva, R, Almeida, OFX, Patchev, V . Glucocorticoid antagonism: A novel aspect of the stress-protective action of melatonin 79th Annual Meeting of the Endocrine Society, Minneapolis, USA, 11-14 June, 1997. Patchev, V, Konakchieva, R, Almeida, OFX . Melatonin as a stress protectant: Attenuation of glucocorticoid-induced impairment of pituitary-adrenal regulation.International Colloquium BIOCLOCKS,97, The Photic System and Time Measurement in Vertebrates, Poitiers, France, 9-11 July, 1997. Konakchieva , R, Manchev, S , Patchev, V . Melatonin counteracts stress- and glucocorticoid-induced dysregulation of the hypothalamo-pituitary-adrenal axis. 8th International Symposium on Immunology of Reproduction, Varna, Bulgaria, 12-14 October, 1997. Manchev, S., Mitev, Y., Konakchieva, R. Glucocorticoid receptors - target of the immunomodulatory action of melatonin ? 8th International Symposium on Immunology of Reproduction, Varna, Bulgaria, 12-14 October, 1997. Konakchieva, R., Manchev, S., Pevet, P., Masson-Pevet, M. Glucocorticoids modify the expression and binding of melatonin receptors in the immune system. Hanseatic Endocrine Conference: Melatonin after Four Decades, Hamburg, Germany, 27-30 August, 1998. Konakchieva, R, Pevet, P, Masson-Pevet, M. Glucocorticoids-melatonin interactions in immune tissue of rats:implications for neuroendocrine-immune homeostasis. Annual Meeting of the French Society of Ecophysiology, Strasbourg, France, 13th November, 1998. Kumanov, P., Tomova, A., Manchev, S., Konakchieva, R. Longitudinal study of the circadian profile of plasma melatonin and cortisol in patients with Cushing,s syndrome. 9th Meeting ENEA, Odense, Denmark, 3-7 Sept 1999. Konakchieva, R., Manchev, S., Pevet, P., Masson-Pevet, M. Expression of melatonin receptors in the immune system:significance in glucocorticoid-mediated immunity. 4th Int Congr ISNIM, Lugano, Switzerland, 29 Sept-2 Oct 1999. Стаменов Г., ТОДОРОВ П., Димитров Й., Новачков В., Конакчиева Р. Криоконсервацията и трансплантацията на човешка овариална тъкан – завръщане от бъдещето. ІХ Национален Конгрес по акушерство и гинекология (с международно участие), 27-30 Септември 2001, Варна: 1.5.7 ТОДОРОВ П., Стаменов Г., Новачков В., Димитров Й., Конакчиева Р. Култивиране на човешки овариални клетки и фрагменти. ІХ Национален Конгрес по акушерство и гинекология (с международно участие), 27-30 Септември 2001, Варна: 1.5.8 ТОДОРОВ П., Стаменов Г., Новачков В., Димитров Й., Конакчиева Р. Криоконсервация на човешка овариална тъкан. ІХ Национален Конгрес по акушерство и гинекология (с международно участие), 27-30 Септември 2001, Варна: 1.5.9 Stamenov G., TODOROV P., Konakchieva R. In vitro evaluation tests of the functional viability of human ovarian tissue before and after exposure to cryoprotectants. Climacteric 2002, 5, Suppl.1: F-01-04 (IF=2.15) Stamenov G., TODOROV P., Konakchieva R., Novachkov V., Dimitrov Y. The functional viability of human ovarian tissue before and after freezing at –196. Gynecological Endocrinology 2002, 16, Suppl.1: P-53 (IF=1.36) TODOROV P., Stamenov G., Konakchieva R., Dimitrov Y., Novachkov V. Cryobanking of human ovarian tissue – experience from Bulgaria. 1st World Congress on Ovarian Cryopreservation & Ovarian Transplantation, 27-28 June 2003, Brussels Konakchieva R. Neuroendocrine-immune homeostasis by melatonin. E.C.Qua.L. 1, Suppl. 2003, pp 61. Стаменов Г., ТОДОРОВ П., Димитров Й., Новачков В., Конакчиева Р., Тодоров Я. Криоконсервираната човешка овариална тъкан при жени с малигнени хематологични заболявания – новата надежда. 7-ми Национален Конгрес по клинична и трансфузионна хематология. 9-10 Октомври 2003, София 6-та Национална гинекологична конференция, февруари 2003, Банско 1-ва съвместна национална конференция по акушерство, гинекология, анестезиология и реанимация. 16-18 Октомври 2003, Сандански TODOROV P., Stamenov G., Konakchieva R., Dimitrov Y., Novachkov V. In-vitro evaluation tests of the functional viability of human ovarian tissue before and after freezing. X Ybilee International Symposium of Immunology of Reproduction. 4-6 September2003, Varna Konakchieva R, Manchev S, Tomova A, Kumanov P. Neuroendocrine and immune correlates of impaired hypothalamo-pituitary-adrenal function. Exp Clin Endocrinol Diabetes 2005; 113: 22-23 (IF=1.356) Avtanski D., D. Seto-Young, R. Konakchieva, L. Poretsky Insulin- independent and insulin-sensitizing effects of thiazolidinediones in human ovary. In Proceedings: 11th Int. Symp. on Immunology of Reproduction, Varna, 2-4 June 2006. Avtanski D., D. Seto-Young, R. Konakchieva, L. Poretsky The human ovary – target of PPAR-γ mediated action of thiazolidinediones. In Proceedings: 7th National Congress of Sterility, Contraception and Hormone therapy with international participation, Borovetz, 19-22 of March 2006. Dineva J., I. Vangelov, G. Nikolov, R. Konakchieva, J. Martinova, M. Ivanova In vitro study on the role of epidermal growth factor, progesterone and cyclc guonosine monophosphate on granuslose cells survival. In Proceedings: 11th Int. Symp. of Immunology of Reproduction, Varna, 2-4 June 2006. Todorov P., R. Konakchieva, J. Dimitorv, N. Chub, J. Petrenko Cryopreservation of human embryonic stem cells. In Proceedings: 7th National Congress of Sterility, Contraception and Hormone therapy with international participation, Borovetz, 19-22 of March 2006 Dineva J, I. Vangelov, G. Nikolov, R. Konakchieva, M. Ivanova Comparative studies of some parametters for success in patients treated with GnRHa (Decapeptyl) and GnRHant (Orgalutran) from assisted reproduction program. In Proceedings: 8th National Congress of Infertility, Contraception and Hormone-replacement therapy and Gynaecological Endoscopy with international participation, Borovetz, 17-19 of March 2007. Dineva J, I. Vangelov, R. Konakchieva, Ts. Stefanova, M. Ivanova Studies on the immunoendocrine regulation of cell survival and apoptosis in preovulatory human follice. In Proceedings: XIIIth Symposium of Czech reproductive immunologists with international participation, Zdar nad Sazavou, 24-27 May, 2007. Dineva J, I. Vangelov, G. Nikolov, R. Konakchieva, Ts. Stefanova, M. Ivanova Study on the survival role of ANP-cGMP-P and NO in human periovulatory follicle. In Proceedings: X International congress of reproductive immunology, Opatija, Croatia, June 10-14, 2007; A.J.R.I., V.57, 6, 2007. Wawrek I, R. Konakchieva. In-vitro study of the effect of melatonin and glucocorticoids on Interleukin-1beta stimulated granulose cell function. In Proceedings: 3rd EMBIC Summer School, Jena, September 3-7 2007. Ivanova W., I. Wawrek, R. Konakchieva Influence of endocrine and paracrine factors on the functional characteristics of spermatozoa of men with idiopathic infertility. In Proceedings: 9th National Congress of Infertility, Contraception, HRP and Gynaecological Endoscopy with International Participation, 11-14 April, 2008. Georgiev G., I. Wawrek, R. Konakchieva Effects of growth factors and glucocorticoids on the steroidogenic response of human granulosa cells in vitro. In Proceedings: 9th National Congress of Infertility, Contraception, HRP and Gynaecological Endoscopy with International Participation, 11-14 April, 2008. 36. Taushanova P, R. Konakchieva. Immunomodulation by melatonin-sensitive mechanisms of immune response and apoptosis. 12th International Symposium for Immunology of Reproduction, Varna, Bulgaria, 25-27 June 2009. 37. Konakchieva, R, Gulenova D, Todorov P, Dimitrov Y. Cryopreservation of cord blood haematopoietci stem cells – Bulgarian exeriene. 1st Int Congres on Controversies in Crypreservation of Stem cells, Reproductive tissue &Organs. Valencia, Spain, 22-25 April 2010 38. Georgiev, G., Pastuschek, J., Konakchieva, R. (2012). Insulin-dependent estradiol response under chronic glucocorticoid treatment of human granulose cells in-vitro: modulation by melatonin. In: Abstracts. 13th International Symposium for Immunology of Reproduction, Varna, Bulgaria 22–24 June 2012. American Journal of Reproductive Immunology, 67 (Suppl. 1), pp. 30. 39. Georgiev, G., Dimitrov, R., Todorov, P., Dimitrov, Y., Konakchieva, R. (2012). Melatonin receptors in human spermatozoa – new findings and relevance to assisted reproduction, American Journal of Reproductive Immunology 67 (Suppl. 2) (2012) pp.126. 40. Konakchieva, R.(2012) Physiological role of melatonin in human reproductive system – signaling, targets and receptor localization. In: INVITED SPEAKER ABSTRACTS. 13th International Symposium for Immunology of Reproduction, Varna, Bulgaria 22–24 June 2012. American Journal of Reproductive Immunology 67 (Suppl. 1) (2012) pp. 21. 41. Georgiev, G., R Dimitrov, P Todorov, Y Dimitrov, R Konakchieva. (2012). Membrane melatonin receptor type 1 expression in human ejaculated spermatozoa. In Abstracts: 13th International Symposium for Immunology of Reproduction, Varna, Bulgaria 22–24 June 2012. American Journal of Reproductive Immunology 67 (Suppl. 1), pp. 29 |