Лаборатория по биофизикохимия / Физикохимия / Катедри / Структура / Факултет по химия и фармация / Факултети / Университетът / Начало - Софийски университет "Св. Климент Охридски"

Състояние, електрични и реологични свойства на моделни 2D системи: монослоеве, липозомни бислоеве, суспензии от наночастици и нанокапсули; организация на ензимни и фотохимични реакции на повърхността, състояние, електрични и реологични свойства на моделни монослоеве на биополимери от растителен произход. Атомно-силова микроскопия (AFM).

Международно сътрудничество:

Laboratory of Enzymology at Interfaces and Physiology of Lipolysis, CNRS, Marseilles, France

Laboratory of Particle Vectorisation, University of Angers, France

Laboratory of Enzyme Design, Novo Nordisk, Denmark

Nanoscience Center, University of Copenhagen, Denmark

Учебна дейност:

Лабораторията се занимава с обучение на студенти от всички образователни степени.

Бакалавърски курсове

Лекции и упражнения по: физикохимия с колоидна химия

Магистърска програма: медицинска и фармакологична биофизикохимия, (координирана от лабораторията)

Лекции и упражнения по: биофизикохимия, колоидно-дисперсни системи в медицината и фармацията

Ръководство на дипломни работи

Докторантури

Избрани публикации:

Georgiev, P., Simeonova, S., Mihaylov, L., Nihtianova, D., Balashev, K., “Study of the Kinetics of Nucleation and Growth of Silver Nanoparticles: UV-Visible Spectroscopy vs. Atomic Force Microscopy and Transmission Electron Microscopy”, Comptes Rendus de L'Academie Bulgare des Sciences, Volume 77, Issue 9, Pages: 1277 – 1284, 2024, doi:10.7546/CRABS.2024.09.02

Karakashev, S. I., Ivanova-Stancheva, D., Grozev, N. A., Mircheva, K., “Behavior of froth in absence and presence of particles”, Minerals Engineering, Volume 212, Pages: 108715-0, 2024, doi: 10.1016/j.mineng.2024.108715

Eftekhari, M., Schwarzenberger, K., Karakashev, S. I., Grozev, N. A., Eckert, K., “Oppositely charged surfactants and nanoparticles at the air-water interface: Influence of surfactant to nanoparticle ratio”, Journal of Colloid and Interface Science, Volume 653, Part B, Pages: 1388-1401, 2023, doi: 10.1016/j.jcis.2023.09.038

Teodosiev, D., Bouzekova-Penkova, A., Simeonova, S., Grozev, N., “Contact angle and AFM analysis of glassy carbon coatings after an extended stay on the International Space Station (ISS)”, Comptes Rendus de L'Academie Bulgare des Sciences, Volume 76, Issue 2, Pages: 256 – 263, 2023, doi: 10.7546/CRABS.2023.02.10

Tsenova-Ilieva, I., Simeonova, S., Karova, E., “Atomic force microscopy study on the effect of different irrigation regimens on the surface roughness of human root canal dentin”, Nigerian Journal of Clinical Practice, Volume 25, Issue 3, Pages: 261 – 266, 2022, doi:10.4103/njcp.njcp_1379_21

Mircheva, K., Grozev, N., Petrova, S. D., Ivanova, Tz., Panaiotov, I., Balashev, K. T., “The enzymatic action of Vipoxin on insoluble long-chain phospholipid Langmuir monolayers”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 629, 2021, doi: 10.1016/j.colsurfa.2021.127469

Stoyanova, D., Stambolova, I., Shipochka, M., Boshkova, N., Simeonova, S., Grozev, N., Avdeev, G., Dimitrov, O., Boshkov, N., “Protective efficiency of ZrO2/chitosan “sandwich” coatings on galvanized low-carbon steel”, Coatings, Volume 11, Issue 9, Article number 1103, 2021, doi: 10.3390/coatings11091103

Georgiev, P., Simeonova, S., Tsekov, R., Balashev, K., “Dependence of Plasmon Spectra of Small Gold Nanoparticles from Their Size: an Atomic Force Microscopy Experimental Approach”, Plasmonics, Volume 15, Issue 2, Pages: 371 – 377, 2020, doi: 10.1007/s11468-019-010344

Georgiev, P., Chanachev, Al., Simeonova, S., Mihaylov, L., Nihtianova, D., Ivanova, Tz., Balashev, K., “A new method for studying the kinetics of synthesis of gold nanoparticles in hexadecylanilin monolayer at the air/water interface by means of atomic force microscopy”, Comptes Rendus de L'Academie Bulgare des Sciences, Volume 73, Issue 2, Pages: 197 – 202, 2020, doi:10.7546/CRABS.2020.02.07

Anchev, B. A., Tsekova, D. S., Mircheva, K. M., Grozev, N. A., “Monolayer formed by l-Asp-based gemini surfactants self-assembled in 1D nanostructures”, RSC Advances, Volume 9, Issue 57, Pages: 33071-33079, 2019, doi: 10.1039/C9RA06390K

Simeonova, S., Georgiev, P., Exner, K.S., Mihaylov, L., Nihtianova, D., Koynov, K., Balashev, K., “Kinetic study of gold nanoparticles synthesized in the presence of chitosan and citric acid”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 557, Pages: 106 – 115, 2018, doi: 10.1016/j.colsurfa.2018.02.045

Chanachev, S. Al., Simeonova, S.S., Georgiev, P.D., Ivanova, Tz. N., Petrova, S.D., Balashev, K.T., “Characterization by atomic force microscopy of gold nanoparticles functionalized with azocasein for protease colorimetric enzyme assay”, Bulgarian Chemical Communications, Volume 50, Issue 2, Pages: 223 – 227, 2018

Tsekov, R., Georgiev, P., Simeonova, S., Balashev, K., “Quantifying the blue shift in the light absorption of small gold nanoparticles”, Comptes Rendus de L'Academie Bulgare des Sciences, Volume 70, Issue 9, Pages: 1237 – 1246, 2017, doi: 10.48550/arXiv.1702.04513

Chanachev, Al., Simeonova, S., Georgiev, P., Balashev, K., Ivanova, Tz., Panaiotov, I., “Monolayer kinetic model of formation of gold nanoparticles by reducing agents hexadecylaniline or bovine serum albumin”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 508, Pages: 1 – 7, 2016, doi: 10.1016/j.colsurfa.2016.08.005

Georgiev, P., Simeonova, S., Chanachev, Al., Mihaylov, L., Nihtianova, D., Balashev, K., “Acceleration effect of copper (II) ions on the rate of citrate synthesis of gold nanoparticles”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 494, Pages: 39 - 48, 2016, doi: 10.1016/j.colsurfa.2015.12.031

Panaiotov, I., Ivanova, Tz., Balashev, K., Grozev, N., Minkov, I., Mircheva, K., “Interfacial reorganization of molecular assemblies used as drug delivery systems”, Chemistry: Bulgarian Journal of Science Education, Volume 24, Issue 6, Pages: 891-921, 2015

K. Mircheva, M. Gonnet, K. Balashev, Tz. Ivanova, F. Boury, I. Panaiotov, “Properties of -carotene and retinoic acid in mixed monolayers with dipalmitoylphosphatidylcholine (DPPC) and Solutol”,Colloids and Surfaces A: Physicochem Eng Aspects, .460 (2014) 209.

Tz. Ivanova, K. Mircheva, K. Balashev, I. Minkov, P. Saulnier and I. Panaiotov, “Interfacial behavior of lipid nanocapsules spread on model membrane monolayers”, Coll. Polym. Sci, 292 (6) (2014) 1307.

A.C.Groo, K. Mircheva, J. Bejaud, C. Aihas, I.Panaiotov, P. Saulnier, Tz. Ivanova, F. Lagarce, - Development of 2D and 3D Mucus Models and Their Interactions with Mucus Penetrating Paclitaxel- loaded Lipid Nanocapsules, Pharmaceutical Research, 31 (7) (2014) 1753.

I. Minkov, K. Mircheva, N.Grozev, Tz. Ivanova, I. Panaiotov – Properties of mixed monolayers of clinical lung surfactant, serum albumin and hydrophilic polymers, Colloids and Surfaces B: Biointerfaces, 101 (2013) 135-142.

P. Georgiev, A. Bojinova, B. Kostova, D. Momekova, T. Bjornholm, K.Balashev, „Implementing atomic force microscopy (AFM) for studying kinetics of gold nano-particle's growth” Colloids Surf A: Physicochem Eng Aspects, 434 (2013) 154

K. Mircheva, Tz. Ivanova, I. Panaiotov, R. Verger, ”Hydrolysis of mixed monomolecular films of tricaprylin/dilauroylphosphatidylcholine by lipase and phospholipase A2”, Colloids and Surfaces B: Biointerfaces , 86 (2011) 71.

K. Balashev, Tz.Ivanova, K. Mircheva, I.Panaiotov, „Savinase proteolysis of insulin Langmuir monolayers studied by surface pressure and surface potential measurements accompanied by atomic force microscopy (AFM) imaging” Journal of Colloid and Interface Science 360 (2) (2011) 654.

K. Mircheva, Tz. Ivanova, I. Panaiotov, V. Dusel, F. Boury, “Enzymatic proteolysis of alfa gliadin monolayer spread at the air water interface”, J. Coll.Int. Sci., 347 (2010) 69.

K. Mircheva, I. Minkov, Tz. Ivanova, I. Panaiotov, J.E.Proust, R. Verger, “Comparative study of lipolysis by PLA2 of DOPC substrates organized as monolayers, bilayer vesicles and nanocapsules”,Colloids and Surfaces B:Biointerfaces, 67 (2008) 107.

I. Minkov, Tz. Ivanova, I. Panaiotov, J. Proust, P. Saulnier, “Reorganisation of lipid nanocapsules at air-water interface: 1. Kinetics of surface film formation” Colloids and Surfaces B: Biointerfaces, 45 (2004) 32.

N.Grozev, V..Aguié-Béghin, Tz.Ivanova, S.Baumberger, B.Cathala, R.Douillard, I.Panaiotov,“State, electrical and rheological properties of model and dioxan isolated lignin films at the air-water interface” Coll. Polym. Sci., 280 (2002) 798.

I. Panaiotov, R. Verge, “Enzymatic reactions at the interface”, in Physical Chemistry of Biological Interfacers, ed. by W. Norde and A. Baszkin, Elzevier (2000), 359.

C.Vassilieff, I.Panaiotov, E. D. Manev, J.E. Proust and Tz. Ivanov, “Kinetics of liposome disintegration from foam film studies: Effect of the lipid bilayer phase state” Biophysical Chemistry: 58 (1996) 97.