тел: 02 8167 214
е-mail: ivayloi@biofac.uni-sofia.bg
Образование:
Mагистър по “Органична и аналитична химия”, Химически факултет на СУ “Св. Кл. Охридски”, 1986 г.
Доктор – “Свързване на химическото и фазовото равновесие при ензимно-катализирания пептиден синтез”, 1998г.
Заемани длъжности:
Биологически факултет на СУ “Св. Кл. Охридски”:
н.с. III ст.; 1989 г.
н.с. II ст.; 1994 г.
срарши асистент; 1996 г.
главен асистент; 1998 г.
доцент; 2005
Учебно-преподавателски профил:
Лекции и упражнения по “Биоорганична химия” и “Хидрология и Хидрохимия”
Научни интереси: Биологична химия, хроматография (вкл. ВЕТХ), биодеградация.
Членство в научни организации:
Европейско пептидно дружество
Участие в начучни роекти:
Teacher in TEMPUS – Project SJEP-114545/96 – European Master Degree in Environmental Biotechnology;
Inco-Copernicus Project No IC-15-CT-98-0137 (1998-2002) on “Bioremediation Techniques for Detoxication of Hazardous Pollutants in Industrial Waters and Sludges”
Списък на публикациите:
1. N. Stambolieva, N. Mateeva, I. Ivanov, V. Yomtova, (1989) “A New Substrate for Chymotrypsin Possessing both Chromogenic and Fluorogenic Properties”, 5th International Conference on CHEMISRY AND BIOTECHNOLOGY OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS, September 18-23, Varna, BULGARIA, 119-123.
2. N. Stambolieva, N. Dambadardja, P. Christova, I. P. Ivanov, V. M. Yomtova, (1995) “Kinetic Analysis of Aspartic Proteinases from the Fungal Strain Humicola Lutea 120-5: I. Intramolecularly-Quenched Fluorescent Peptide Substrate”, Compt. Rend. Acad. Bulg. Sci. 48, 63-66.
3. T. Genkov, I. Ivanov, I. Ivanova, (1996) “Analysis of Cytokinins by Immunoassay and High Performance Liquid Chromatography of in vitro cultured Dianthus caryophyllus”, Bulg. J. Plant Physiol. 22, 95-104.
4. Y. Topalova, R. Dimkov, I. Ivanov, S. Sergieva, R. Arsov, (1998) “Ortho-nitrophenol Removal in Two Types Activated Sludge: The Role of Microbiological and Enzymological Adaptation”, Biotechnol. & Biotechnol. Eq. 12, 91-95.
5. И. П. Иванов, (1998) “Свързване на химическото и фазовото равновесие при ензимно-катализирания пептиден синтез”, Автореферат на дисертация за получаване на научната и образователна степен “Доктор”.
6. Y. I. Topalova, I. P. Ivanov, M. K. Krusteva, R. J. Dimkov, (1998) “Adaptation of Activated Sludge from Water Treatment Plant in Oil Chemical Company - Bourgas Toward Biodegradation of PCP”, Seventh Symposium Ecology’98, June 4-6, Bourgas, BULGARIA, vol. 7, 74-80.
7. I. Ribarova, J. Topalova, I. Ivanov, D. Kozuharov, K. Kukurin, R. Dimkov, (2001) “Pentachlorphenol biodegradation in anaerobic and aerobic continuous flow processes”, Biotechnol. & Biotechnol. Eq. 15, 86-89.
8. D. Kozuharov, J. Topalova, R. Dimkov, I. Ribarova, I. Ivanov, (2001) “Bioindicative potencial of the Micro- and Metafauna in the Activated sludge towards oNP”, Biotechnol. & Biotechnol. Eq. 15, 92-99.
9. Jana I. Topalova, Raycho I. Dimkov, Irina S. Ribarova, Ivailo P. Ivanov, Dimitar S. Kozuharov, Mariana V. Velikova, Lidiya D. Angelova, (2001) “Dehalogenase Activity - Indicator for the Initial Detoxication Of Pentachlorophenol at the step by step Adapted Activated Sludge”, J. Int. Res. Public. (Serial online), Issue 1. http://ejournal.topcities.com/Contents/Issue_2/1/1_2002.htm
10. M. Guncheva, I. Ivanov, N. Stambolieva, (2002) “Kinetic Studies on the Arylamidase Activity Exhibited by Proteinases Belonging to Different Mechanistic Classes”, Compt. Rend. Bulg. Acad. Sci. 55, 41-44.
11. I. Ivanov, M. Dimitrova, P. Galabov, A. Dikov, (2002) “Fluorescent Histochemical Demonstration of Alanine Aminopeptidase Using a Newly Synthesized Substrate”, Acta Morphologica et Anthropologica, 7, 68-71.
12. R. Krieg, M. Dimitrova, I. Ivanov, A. Dikov, (2003) “Tetrazolium Salt Method for the Histochemical Demonstration of Aminopeptidase A”, Acta Morphologica et Anthropologica, 8, 57-62.
13. Y. Topalova, D. Kozuharov, I. Ivanov, R. Dimkov, I. Ribarova, (2003) “Biotransformation of 2,4,5-trichlorophenol and 3,4-dichlorophenol: Relationship activity/population structure of aerobic activated sludge”, Biotechnol. & Biotechnol. Eq. 17, 37-41.
14. Y. Topalova, R. Dimkov, D. Kozuharov, I. Ribarova, I. Ivanov, M. Nunes, C. Cheng, (2003) “Design for an effective control of the PCP-detoxication in HBR”, Biotechnol. & Biotechnol. Eq. 17, 42-51.
15. D. Kozuharov, Y. Topalova, R. Dimkov, I. Ivanov, I. Ribarova, E. Koseva, C. Van Keer, (2003) “Adaptation limits of the changes of the micro- and metafauna in the activated sludge towards PCP in aerobic and anaerobic conditions flow process”, Biotechnol. & Biotechnol. Eq. 17, 58-67.
16. D. Kozuharov, Y. Topalova, R. Dimkov, I. Ivanov, I. Ribarova, C. Cheng, M. Nunes, (2003) “Adaptation, structure of the micro- and metafauna in activated sludge from the up flow reactor during the PCP-detoxication”, Biotechnol. & Biotechnol. Eq. 17, 68-75.
17. Y. Topalova, I. Ribarova, R. Dimkov, D. Kozuharov, I. Ivanov, (2003) “Sustainability of municipal WWTPs towards industrial discharges. A possible rehabilitation technology”, Biotechnol. & Biotechnol. Eq. 17, 87-95.
18. I. Ribarova, Y. Topalova, R. Dimkov, I. Ivanov, D. Kozuharov, M. Nunes, C. Cheng, (2003) “Four activated sludge technologies for pentachlorophenol removal”, Biotechnol. & Biotechnol. Eq. 17, 96-103.
19. N. A. Stambolieva, I. P. Ivanov, V. M. Yomtova, (1992) “N-Anthraniloyl-Ala-Ala-Phe-4-nitroanilide, a Highly Sensitive Substrate for Subtilisins”, Arch. Biochem. Biophys. 294, 703-706.
20. B. Stoineva, B. P. Galunsky, V. S. Lozanov, I. P. Ivanov, D. D. Petkov, (1992) "Enzymic Synthesis Design and Enzymic Synthesis of Aspartame", Tetrahedron 48, 1115-1122.
21. I. P. Ivanov, N. P. Todorov, D. D. Petkov, (1993) "Thermodynamics of Enzymic Synthesis of Solid-Phase Peptides", Tetrahedron 49, 2307-2316.
22. P. Dalev, An. Ljbomirova, I. Ivanov, (1996) “Enzyme Extraction, Functional Properties and Application of Leaf Protein Fractions of Nettle”, Biotechnol. Lett. 18, 107-110.
23. P. Dalev, I. Ivanov, A. Ljubomirova, (1997) "Enzyme Modification of Keratin Protein Hydrolyzates with Lysine Aimed to Increase the Biological Value", J. Sci. Food Agric. 73, 242-244.
24. I. P. Ivanov, V. Kasche, D. D. Petkov, (1997) "Thermodynamics of enzymic peptide synthesis in biphasic aqueous-organic systems: Coupling of the chemical and phase equilibria", Biocatalysis & Biotransformation 14, 181-194.
25. I. P. Ivanov, V. M. Yomtova, D. D. Petkov, (1997) “Semispecific Ester Substrates of Trypsin as Acyl Donors in Kinetically Controlled Peptide Synthesis”, Biocatalysis & Biotransformation 14, 195-204.
26. Y. Topalova, I. Ivanov, R. Dimkov, (1997) “Regulating Possibilities of Heavy Metals on the PCP-Biodegradation by Pseudomonas aureofaciens AP9”, International Symposium ENVIRONMENTAL BIOTECHNOLOGY, April 21-23, Oostende, BELGIUM, 223-226 (eds. H. Verachtert and W. Verstrate).
27. L. Nechev, Al. Dobrev , I. Ivanov, Tz. Cholakova, (1998) “The Reaction of Ethyl 2-Chloroacetoacetate with 2-(Alkylamino) Alcohols: an Unexpected Formation of the 2-Methyloxazolidine Ring”, J. Chem Res. (S) 30-31.
28. T. Noronkoski, I. B. Stoineva, I. P. Ivanov, D. D. Petkov, I. Mononen, (1998) “Glycosylasparaginase - Catalyzed Synthesis and Hydrolysis of beta-Aspartyl Peptides”, J. Biol. Chem. 273, 26295-26297.
29. V. M. Yomtova, S. D. Kyurkchiev, N. N. Slavcheva, I. P. Ivanov, (1998) “Antibody - Catalysed Peptide Nitroanilide Hydrolysis Using a New Type of Hapten”, Biocatalysis & Biotransformation 16, 307-316.
30. J. Topalova, C. Van Keer , I. Ivanov, R. Dimkov, (1998) “Bioremediation Potential of Aerobic Sludge Towards Combination oNP/PCP”, Procceeding of 12th-Forum on APPLIED BIOTECHNOLOGY, September 24-27, Gent, BELGIUM, Med. Fac. Landbouww. Univ. Gent, 63/4b, 1901-1905.
31. J. Topalova, R. Dimkov, I. Ribarova, D. Kozuharov , I. Ivanov, C. Van Keer, (1999) “Feasibility Study of Bioremediation Potential of Activated Sludge Towards PCP: Integrated Approach”, Procceeding of 13th-Forum on APPLIED BIOTECHNOLOGY, September, Gent, BELGIUM, Med. Fac. Landbouww. Univ. Gent, 64/5a.
32. A. Dikov , I. Ivanov, M. Dimitrova, R. Krieg, K.-J. Halbhuber, (1999) “New Method for the Histochemical Demonstration of Dipeptidyl Aminopeptidase I Activity Using a Novel Antraquinoyl Hydrazide Substrate”, Cell. Mol. Biol. 45, 1229-1235.
33. A. Dikov, M. Dimitrova, I. Ivanov, R. Krieg, K.-J. Halbhuber, (2000) “Original Method for the Histochemical Demonstration of Tripeptidyl Aminopeptidase I”, Cell. Mol. Biol. 46, 1219-1225.
34. J. Topalova, I. Ribarova, R. Dimkov, D. Kozucharov, I. Ivanov, (2001) “Sustainability of municipal WWTPs towards Industrial discharges. A possible rehabilitation technology”, Proceedings of International Conference on Sustainability of Water and Environmental Systems Rehabilitation, September 24-26, Banja Luka, BOSNIA and HERCEGOVINA, 244-256.
35. I. Ribarova, J. Topalova, I. Ivanov, D. Kozuharov, R. Dimkov, C. Cheng, (2002) “Anaerobic Sequencing Batch Reactor as an Innitiating Stage in Complete Pentachlorophenol Biodegradation”, Wat. Sci. Technol. 46, 565-569.
36. Ivaylo P. Ivanov, Hristina J. Miteva, and Vihra M. Yomtova, (2003) “A simplified equation allowing the determination of kinetic constants of ‘‘invisible’’ substrates”, Anal. Biochem. 323, 247-248.
37. M. Guncheva, I. Ivanov, B. Galunsky, N. Stambolieva, J. Kaneti, (2004) “Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145 – ArgB263”, Eur. J. Biochem. 271, 2272-2279.